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Objectives To determine serum levels of CCL13 and its clinical associations in patients with SSc. Methods Serum CCL13 levels were examined by enzyme-linked immunosorbent assay in 80 patients with SSc, 20 patients with systemic lupus erythematosus (SLE), 20 patients with dermatomyositis (DM), 29 patients with atopic dermatitis (AD) and 50 healthy individuals. Results Mean +/- SD serum CCL13 levels were elevated in patients with SSc (81.3 +/- 55.8 pg mL(-1)) compared with healthy controls (15.0 +/- 9.9 pg mL(-1); P \u003c 0.001) and patients with SLE (22.0 +/- 6.9 pg mL(-1); P \u003c 0.001), DM (24.4 +/- 36.1 pg mL(-1); P \u003c 0.001) and AD (18.0 +/- 6.4 pg mL(-1); P \u003c 0.001). Among patients with SSc, there were no differences in serum CCL13 levels between limited cutaneous SSc and diffuse cutaneous SSc. In a longitudinal study, CCL13 levels were generally unchanged during the follow-up. 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CCL13 could be a promising serological marker for SSc.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "The British journal of dermatology, 162(2), pp.332-336; 2010", "subitem_description_type": "Other"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "19747218", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/j.1365-2133.2009.09507.x", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© The Authors 2010. This is the author\u0027s version of the work. 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CCL13 is a promising diagnostic marker for systemic sclerosis.
http://hdl.handle.net/10069/24670
http://hdl.handle.net/10069/246707bbbe0b5-666c-4734-b47f-41443e6b6a81
名前 / ファイル | ライセンス | アクション |
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BJD162_332.pdf (8.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-03-07 | |||||
タイトル | ||||||
タイトル | CCL13 is a promising diagnostic marker for systemic sclerosis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CCL13 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemokine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enzyme-linked immunosorbent assay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic sclerosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yanaba, Koichi
× Yanaba, Koichi× Yoshizaki, Ayumi× Muroi, Eiji× Hara, Toshihide× Ogawa, Fumihide× Shimizu, Kazuhiro× Hasegawa, Minoru× Fujimoto, Manabu× Takehara, Kazuhiko× Sato, Shinichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Summary Background Previous studies suggest that CCL13 may have some role in the pathogenesis of systemic sclerosis (SSc). Objectives To determine serum levels of CCL13 and its clinical associations in patients with SSc. Methods Serum CCL13 levels were examined by enzyme-linked immunosorbent assay in 80 patients with SSc, 20 patients with systemic lupus erythematosus (SLE), 20 patients with dermatomyositis (DM), 29 patients with atopic dermatitis (AD) and 50 healthy individuals. Results Mean +/- SD serum CCL13 levels were elevated in patients with SSc (81.3 +/- 55.8 pg mL(-1)) compared with healthy controls (15.0 +/- 9.9 pg mL(-1); P < 0.001) and patients with SLE (22.0 +/- 6.9 pg mL(-1); P < 0.001), DM (24.4 +/- 36.1 pg mL(-1); P < 0.001) and AD (18.0 +/- 6.4 pg mL(-1); P < 0.001). Among patients with SSc, there were no differences in serum CCL13 levels between limited cutaneous SSc and diffuse cutaneous SSc. In a longitudinal study, CCL13 levels were generally unchanged during the follow-up. Conclusions Serum CCL13 was specifically increased in patients with SSc, but not in patients with SLE, DM or AD or in healthy controls. CCL13 could be a promising serological marker for SSc. | |||||
書誌情報 |
The British journal of dermatology 巻 162, 号 2, p. 332-336, 発行日 2010-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00070963 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13652133 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00574479 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19747218 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1365-2133.2009.09507.x | |||||
権利 | ||||||
権利情報 | © The Authors 2010. This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in British Journal of Dermatology, 162(2), pp.332-336. http://dx.doi.org/10.1111/j.1365-2133.2009.09507.x | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The British journal of dermatology, 162(2), pp.332-336; 2010 |