WEKO3
アイテム
The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance.
http://hdl.handle.net/10069/23467
http://hdl.handle.net/10069/23467a1bcbce2-320e-438d-bc77-3179b00bade8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CBI29_472.pdf (1.5 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-08-09 | |||||
| タイトル | ||||||
| タイトル | The sperm mitochondria-specific translocator has a key role in maternal mitochondrial inheritance. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Elimination factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Maternal mitochondrial inheritance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sperm factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tom complex | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tpis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hayashida, Kenji
× Hayashida, Kenji× Omagari, Katsuhisa× Masuda, Jun-ichi× Hazama, Hiroaki× Kadokawa, Yoshiko× Ohba, Kazuo× Kohno, Shigeru |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The mechanism of maternal mitochondrial inheritance in animals involves the selective elimination of sperm mitochondria by the elimination factor of the egg and the sperm mitochondria-specific factor. In vitro fertilization using sperm from isogenic mice incorporating heterospecific mitochondrial DNA (mtDNA) showed that the number of PCR positives of sperm mtDNA in two-cell embryos was significantly increased following sperm incubation with anti-tetratricopeptide repeat-containing protein involved in spermatogenesis (tpis) protein, anti-translocator of mitochondrial outer membrane (Tom) 22 and anti-Tom40 antibodies. The treatment of fertilized eggs with EGTA and other endonuclease inhibitors increased the sperm mtDNA levels. We conclude that the elimination factor, which is probably an endonuclease, is selectively received by the tpis protein of the sperm mitochondrial outer membrane within the egg. It is then transported into the sperm mitochondria by Tom22 and Tom40, where it destroys the sperm mtDNA, establishing the maternal inheritance of mtDNA. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Version of Record (VoR) is available at http://www.cellbiolint.org | |||||
| 書誌情報 |
Cell biology international 巻 29, 号 6, p. 472-481, 発行日 2005-06 |
|||||
| 出版者 | ||||||
| 出版者 | International Federation for Cell Biology | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10656995 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10882014 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 15979907 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.cellbi.2004.09.016 | |||||
| 権利 | ||||||
| 権利情報 | © 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Cell biology international, 29(6), pp.472-481; 2005 | |||||
