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Cyclooxygenase-2 is Involved in the Progression of Thyroid Cancer
http://hdl.handle.net/10069/22060
http://hdl.handle.net/10069/22060fb4f3403-1477-418e-97a0-84c34e245849
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta_54_1_9.pdf (192.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2009-08-03 | |||||
| タイトル | ||||||
| タイトル | Cyclooxygenase-2 is Involved in the Progression of Thyroid Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cyclooxygenase-2 (COX-2) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Thyroid cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | COX-2 inhibitor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Apoptosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mitogen-activated protein kinase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Sugahara, Ikuko
× Sugahara, Ikuko× Ando, Takao× Usa, Toshiro× Kawakami, Atsushi× Ashizawa, Kiyoto× Uga, Tatsuya× Maeda, Shigeto× Kanematsu, Takashi× Eguchi, Katsumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although the inducible form of cyclooxygenase (COX), COX-2, is highly expressed in various cancers and it is also involved in cancer progression, its role in thyroid cancer is not fully understood. We assessed in the situ cyclooxygenase expression in normal thyroids (n=6), Graves' thyroids (n=6), thyroid adenomas (n=12), thyroid follicular (n=15) and papillary carcinomas (n=30). In comparison to the constitutive expression of COX-1, COX-2 was highly expressed in thyroid cancers (90.0% of thyroid papillary carcinomas and 73.3% of thyroid follicular carcinomas) and moderately in thyroid adenomas (25.5%), but barely expressed in normal and Graves' thyroid tissues. This quantitative assessment employed immunohistochemical methods. Thereafter we compared the effect of COX-2 inhibition on a human follicular thyroid carcinoma cell line (WRO), and a human papillary carcinoma cell line (NPA), using selective COX-2 inhibitor(NS-398). The treatment with 50 μM NS-398 suppressed the growth of the COX-2 expressing cells, NPA cells (37.7%;p<0.01) and WRO cells (10.1%;p<0.05). Moreover, at concentrations ? 100 μM, NS-398 induced cell death a mitochondrial dysfunction. In addition, 50 μM of NS-398 inhibited the activation of extracellular signal-regulated kinase in NPA cells after the stimulation with fetal bovine serum. Our results indicate that COX-2 is involved in the progression of thyroid cancer. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 54, 号 1, p. 9-14, 発行日 2009-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508432 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関係URI | ||||||
| 関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/54.9 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia, 54(1), pp.9-14 ; 2009 | |||||
