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Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection.
http://hdl.handle.net/10069/22096
http://hdl.handle.net/10069/2209626cc7514-77c2-4abe-9c5f-ac3c49d71736
名前 / ファイル | ライセンス | アクション |
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IJAA_CA-MRSAandLND_Yanagihara.pdf (720.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-08-25 | |||||
タイトル | ||||||
タイトル | Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pathogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | resistant bacteria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MRSA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | linezolid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yanagihara, Katsunori
× Yanagihara, Katsunori× Kihara, Rie× Araki, Nobuko× Morinaga, Yoshitomo× Seki, Masafumi× Izumikawa, Koichi× Kakeya, Hiroshi× Yamamoto, Yoshihiro× Yamada, Yasuaki× Kohno, Shigeru× Tsukamoto, Kazuhiro× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Many strains of community-acquired meticillin-resistant Staphylococcus aureus (MRSA) have a pore-forming leukotoxin, known as Panton-Valentine leukocidin (PVL), which can cause severe necrotising pneumonia. Linezolid (LZD) is a new antibacterial agent with potent antibacterial activity against MRSA. In this study, a mouse model of haematogenous pulmonary infection was used to compare the efficacies of LZD and vancomycin (VAN) against pulmonary infection caused by PVL-positive S. aureus. Following antibiotic administration for 3 days, the number of viable bacteria (mean+/-standard error of the mean) in the control, VAN and LZD groups was 6.77+/-0.14, 5.29+/-0.27 and 4.25+/-0.33log colony-forming units/lung, respectively. LZD significantly decreased the number of viable bacteria in the lungs compared with the control and VAN groups (P<0.05). The survival rate at Day 7 post-inoculation was higher in the LZD group (100%) than in the VAN group (50%) or the control group (0%). Histopathological examination and cytokine analysis also showed the beneficial efficacy of LZD compared with VAN. In conclusion, LZD significantly reduced bacterial numbers and inflammation in a mouse model of PVL-positive S. aureus haematogenous infection and improved the survival rate of infected mice compared with VAN. LZD is clinically effective against PVL-positive S. aureus. | |||||
書誌情報 |
International journal of antimicrobial agents 巻 34, 号 5, p. 477-481, 発行日 2009-11 |
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18727913 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10778078 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19665359 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijantimicag.2009.06.024 | |||||
権利 | ||||||
権利情報 | Copyright c 2009 Elsevier B.V. and the International Society of Chemotherapy | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International journal of antimicrobial agents, 34(5), pp.477-481; 2009 |