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Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
http://hdl.handle.net/10069/22253
http://hdl.handle.net/10069/22253a104a987-6ba8-475f-8334-eb3af4193247
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Virology_Kubo.pdf (955.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2009-10-16 | |||||
| タイトル | ||||||
| タイトル | Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cathepsin B | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cathepsin L | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ecotropic murine leukemia virus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yoshii, Hiroaki
× Yoshii, Hiroaki× Kamiyama, Haruka× Minematsu, Kazuo× Goto, Kensuke× Mizota, Tsutomu× Oishi, Kazunori× Katunuma, Nobuhiko× Yamamoto, Naoki× Kubo, Yoshinao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently it has been reported that a cathepsin B inhibitor, CA-074Me, attenuates ecotropic murine leukemia virus (Eco-MLV) infection in NIH3T3 cells, suggesting that cathepsin B is required for the Eco-MLV infection. However, cathepsin B activity was negative or extremely low in NIH3T3 cells. How did CA-074Me attenuate the Eco-MLV infection? The CA-074Me treatment of NIH3T3 cells inhibited cathepsin L activity, and a cathepsin L specific inhibitor, CLIK148, attenuated the Eco-MLV vector infection. These results indicate that the suppression of cathepsin L activity by CA-074Me induces the inhibition of Eco-MLV infection, suggesting that cathepsin L is required for the Eco-MLV infection in NIH3T3 cells. The CA-074Me treatment inhibited the Eco-MLV infection in human cells expressing the exogenous mouse ecotropic receptor and endogenous cathepsins B and L, but the CLIK148 treatment did not, showing that only the cathepsin L suppression by CLIK148 is not enough to prevent the Eco-MLV infection in cells expressing both of cathepsins B and L, and CA-074Me inhibits the Eco-MLV infection by suppressing both of cathepsins B and L. These results suggest that either cathepsin B or L is sufficient for the Eco-MLV infection. | |||||
| 書誌情報 |
Virology 巻 394, 号 2, p. 227-234, 発行日 2009-11-25 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00426822 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10960341 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00884454 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 19781728 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.virol.2009.08.045 | |||||
| 権利 | ||||||
| 権利情報 | Copyright c 2009 Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Virology, 394(2), pp.227-234; 2009 | |||||
