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However, the association of this system in systemic sclerosis (SSc) remains unknown. MATERIALS AND METHODS: To determine clinical association of serum levels of HMGB-1 and soluble RAGE (sRAGE) in patients with SSc, sera from 70 patients with SSc and 25 healthy controls were examined by enzyme-linked immunosorbent assay. Sera from tight-skin mice and bleomycin-induced scleroderma mice, animal models for SSc, were also examined. Skin HMGB-1 and RAGE expression was assessed by immunohistochemistry. RESULTS AND DISCUSSION: Serum HMGB-1 and sRAGE levels in SSc were higher than those in controls. Similarly, HMGB-1 and sRAGE levels in animal SSc models were higher than those in control mice. SSc patients with elevated HMGB-1 and sRAGE levels had more frequent involvement of several organs and immunological abnormalities compared to those with normal levels. 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Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity.
http://hdl.handle.net/10069/22498
http://hdl.handle.net/10069/224984eda03d9-1397-46f7-ba8f-112acff63c8b
名前 / ファイル | ライセンス | アクション |
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JCI29_180.pdf (3.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-11-24 | |||||
タイトル | ||||||
タイトル | Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Autoimmune disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HMGB-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RAGE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Systemic sclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Toll-like receptor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshizaki, Ayumi
× Yoshizaki, Ayumi× Komura, Kazuhiro× Iwata, Yohei× Ogawa, Fumihide× Hara, Toshihide× Muroi, Eiji× Takenaka, Motoi× Shimizu, Kazuhiro× Hasegawa, Minoru× Fujimoto, Manabu× Sato, Shinichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | INTRODUCTION: The high mobility group box 1 protein (HMGB-1)/advanced glycation end products (RAGE) system is recently shown to play an important part in immune/inflammatory disorders. However, the association of this system in systemic sclerosis (SSc) remains unknown. MATERIALS AND METHODS: To determine clinical association of serum levels of HMGB-1 and soluble RAGE (sRAGE) in patients with SSc, sera from 70 patients with SSc and 25 healthy controls were examined by enzyme-linked immunosorbent assay. Sera from tight-skin mice and bleomycin-induced scleroderma mice, animal models for SSc, were also examined. Skin HMGB-1 and RAGE expression was assessed by immunohistochemistry. RESULTS AND DISCUSSION: Serum HMGB-1 and sRAGE levels in SSc were higher than those in controls. Similarly, HMGB-1 and sRAGE levels in animal SSc models were higher than those in control mice. SSc patients with elevated HMGB-1 and sRAGE levels had more frequent involvement of several organs and immunological abnormalities compared to those with normal levels. Furthermore, HMGB-1 and sRAGE levels correlated positively with modified Rodnan total skin thickness score and negatively with pulmonary function test. CONCLUSIONS: HMGB-1 and sRAGE expression in the sclerotic skin was more intense than normal skin. These results suggest that elevated serum HMGB-1 and sRAGE levels are associated with the disease severity and immunological abnormalities in SSc. | |||||
書誌情報 |
Journal of clinical immunology 巻 29, 号 2, p. 180-189, 発行日 2009-03 |
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出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02719142 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1573-2592 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10620335 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18825489 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10875-008-9252-x | |||||
権利 | ||||||
権利情報 | c Springer Science+Business Media, LLC 2008 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of clinical immunology, 29(2), pp.180-189; 2009 |