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Overexpression of Cortactin Increases Invasion Potential in Oral Squamous Cell Carcinoma.
http://hdl.handle.net/10069/22909
http://hdl.handle.net/10069/22909a90c1b4c-14eb-49f5-97a9-bb823af4e349
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
POR16_523.pdf (687.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2010-02-12 | |||||
| タイトル | ||||||
| タイトル | Overexpression of Cortactin Increases Invasion Potential in Oral Squamous Cell Carcinoma. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cortactin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | invasion | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | metastasis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RNA interference | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oral squamous cell carcinoma | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamada, Shin-Ichi
× Yamada, Shin-Ichi× Yanamoto, Souichi× Kawasaki, Goro× Mizuno, Akio× Nemoto, Takayuki K |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cortactin, an F-actin binding protein, stabilizes F-actin networks and promotes actin polymerization by activating the Arp2/3 complex. Overexpression of cortactin has been reported in several human cancers. Cortactin stimulates cell migration, invasion, and experimental metastasis. However, the underlying mechanism is not still understood. In the present study, we therefore evaluated the possibility that cortactin could be appropriate as a molecular target for cancer gene therapy. In 70 primary oral squamous cell carcinomas and 10 normal oral mucosal specimens, cortactin expression was evaluated by immunological analyses, and the correlations of the overexpression of cortactin with clinicopathologic factors were evaluated. Overexpression of cortactin was detected in 32 of 70 oral squamous cell carcinomas; significantly more frequently than in normal oral mucosa. Cortactin overexpression was more frequent in higher grade cancers according to T classification, N classifications, and invasive pattern. Moreover, RNAi-mediated decrease in cortactin expression reduced invasion. Downregulation of cortactin expression increased the expression levels of E-cadherin, beta-catenin, and EpCAM. The siRNA of cortactin also reduced PTHrP expression via EGF signaling. These results consistently indicate that the overexpression of cortactin is strongly associated with an aggressive phenotype of oral squamous cell carcinoma. In conclusion, we propose that cortactin could be a potential molecular target of gene therapy by RNAi targeting in oral squamous cell carcinoma. | |||||
| 書誌情報 |
Pathology oncology research 巻 16, 号 4, p. 523-531, 発行日 2010-12 |
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| 出版者 | ||||||
| 出版者 | Springer Netherlands | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 12194956 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1532-2807 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11538284 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20069395 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12253-009-9245-y | |||||
| 権利 | ||||||
| 権利情報 | c Aranyi Lajos Foundation 2010 | |||||
| 権利 | ||||||
| 権利情報 | The original publication is available at www.springerlink.com | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Pathology & Oncology Research, 16(4), pp.523-531; 2010 | |||||
