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Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells.
http://hdl.handle.net/10069/20193
http://hdl.handle.net/10069/2019392b8fb58-1bf7-46a9-833d-29bcff155078
名前 / ファイル | ライセンス | アクション |
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Endocrinology149_5357.pdf (822.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-11-18 | |||||
タイトル | ||||||
タイトル | Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DHMEQ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NF-kappaB | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | paclitaxel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | docetaxel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anaplastic thyroid cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Meng, Zhaowei
× Meng, Zhaowei× Mitsutake, Norisato× Nakashima, Masahiro× Starenki, Dmytro× Matsuse, Michiko× Takakura, Shu× Namba, Hiroyuki× Saenko, Vladimir× Umezawa, Kazuo× Ohtsuru, Akira× Yamashita, Shunichi |
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その他のタイトル | ||||||
その他のタイトル | DHMEQ, a novel NF-{kappa}B inhibitor, enhances anti-tumor activity of taxanes in anaplastic thyroid cancer cells (Author Manuscript title) | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Nuclear factor kappaB (NF-kappaB), as an antiapoptotic factor, crucially affects the outcomes of cancer treatments, being one of the major culprits of resistance to chemotherapy. In this study, we investigated whether dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-kappaB inhibitor, can enhance antitumor activities of taxanes in anaplastic thyroid cancer (ATC) cells. Taxanes induced NF-kappaB activation in ATC cells, which could compromise the therapeutic effect of the drugs. However, DHMEQ, by inhibiting the nuclear translocation of NF-kappaB, completely suppressed the DNA binding capacities of NF-kappaB and lowered the levels of nuclear NF-kappaB protein. Compared with single treatment (either taxane or DHMEQ), the combined treatment strongly potentiated apoptosis, confirmed by cell survival assay; Western blotting for poly (ADP-ribose) polymerase, caspase 3, X-linked inhibitor of apoptosis, and survivin; and flow cytometry for annexin V. Furthermore, we also demonstrate for the first time that the combined treatment showed significantly greater inhibitory effect on tumor growth in a nude mice xenograft model. These findings suggest that taxanes are able to induce NF-kappaB activation in ATC cells, which could attenuate antitumor activities of the drugs, but inhibition of NF-kappaB by DHMEQ creates a chemosensitive environment and greatly enhances apoptosis in taxanes-treated ATC cells in vitro and in vivo. Thus, DHMEQ may emerge as an attractive therapeutic strategy to enhance the response to taxanes in ATCs. | |||||
書誌情報 |
Endocrinology 巻 149, 号 11, p. 5357-5365, 発行日 2008-11 |
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出版者 | ||||||
出版者 | The Endocrine Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00137227 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00635074 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18653704 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1210/en.2008-0279 | |||||
権利 | ||||||
権利情報 | Copyright c 2008 by The Endocrine Society | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Endocrinology, 149(11), pp.5357-5365; 2008 |