WEKO3
アイテム
Induction of tetraspanin 13 contributes to the synergistic anti-inflammatory effects of parasympathetic and sympathetic stimulation in macrophages
http://hdl.handle.net/10069/0002000020
http://hdl.handle.net/10069/0002000020abb8a2e3-3848-404d-8c1c-e4d1c32f6e92
名前 / ファイル | ライセンス | アクション |
---|---|---|
BBRC665_187.pdf (1.9 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2023-07-11 | |||||||||||||||||
タイトル | ||||||||||||||||||
タイトル | Induction of tetraspanin 13 contributes to the synergistic anti-inflammatory effects of parasympathetic and sympathetic stimulation in macrophages | |||||||||||||||||
言語 | en | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Neuro-immune system | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Synergistic anti-inflammatory effect | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Cholinergic anti-inflammatory pathway | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | a7 nicotinic acetylcholine receptors | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | b2 adrenergic receptor | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Tspan13 | |||||||||||||||||
資源タイプ | ||||||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
著者 |
Umene, Ryusuke
× Umene, Ryusuke
× Nakamura, Yasuna
× Wu, Chia-Hsien
× Muta, Kumiko
× Nishino, Tomoya
× Inoue, Tsuyoshi
|
|||||||||||||||||
抄録 | ||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | The autonomic nervous system plays an important role in the regulation of peripheral inflammation. Sympathetic nervous activation stimulates inflammatory gene expression and cytokines, whereas parasympathetic nervous activation suppresses the production of inflammatory cytokines by immune cells. However, most studies on the relationship between the autonomic nervous system and immune processes have analyzed a single branch of the autonomic nerves in isolation. Therefore, this study aimed to examine the effects of sympathetic and parasympathetic stimulation on macrophages, which are controlled by autonomic regulation. Macrophages were stimulated with lipopolysaccharide (LPS) to induce TNF-a. Then, the effects of b2 adrenergic receptor and a7 nicotinic acetylcholine receptor activation on TNF-a production were assessed using concentration-dependent assays. RNA-seq data were also used to identify genes whose expression was enhanced by parasympathetic and sympathetic stimulation. The simultaneous activation of b2 adrenergic receptors and a7 nicotinic acetylcholine receptors suppressed LPS-induced TNF-a production in a concentration-dependent manner. Moreover, simultaneous activation of these receptors had synergistic anti-inflammatory effects and induced Tspan13 expression, thereby contributing to anti-inflammatory mechanisms in macrophages. Our study revealed the synergistic anti-inflammatory effects of the parasympathetic and sympathetic stimulation of macrophages. Our results suggest that targeting both sympathetic and parasympathetic signaling is a promising therapeutic approach for inflammatory diseases. | |||||||||||||||||
言語 | en | |||||||||||||||||
書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 665, p. 187-194, 発行日 2023-05-08 |
|||||||||||||||||
出版者 | ||||||||||||||||||
出版者 | Elsevier B.V. | |||||||||||||||||
言語 | en | |||||||||||||||||
ISSN | ||||||||||||||||||
収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 0006291X | |||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | 10.1016/j.bbrc.2023.04.118 | |||||||||||||||||
権利 | ||||||||||||||||||
言語 | en | |||||||||||||||||
権利情報 | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||
著者版フラグ | ||||||||||||||||||
出版タイプ | AM | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
引用 | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | Biochemical and Biophysical Research Communications, 665, pp.187-194; 2023 | |||||||||||||||||
言語 | en |