Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2023-07-25 |
タイトル |
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言語 |
en |
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タイトル |
Urinary titin N-fragment as a predictor of decreased skeletal muscle mass in patients with interstitial lung diseases |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Hanada, Masatoshi
Ishimatsu, Yuji
Sakamoto, Noriho
Akiyama, Yoshiko
Kido, Takashi
Ishimoto, Hiroshi
Oikawa, Masato
Nagura, Hiroki
Takeuchi, Rina
Sato, Shuntaro
Takahata, Hideaki
Mukae, Hiroshi
Kozu, Ryo
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung disease. We measured urinary N-titin/Cr. Furthermore, we measured the cross-sectional areas of the pectoralis muscles above the aortic arch (PMCSA) and erector spinae muscles of the 12th thoracic vertebra muscles (ESMCSA) to assess muscle mass until 1 year. We examined the correlation between urinary N-titin/Cr and the change in muscle mass. We plotted receiver operating characteristic curves to estimate the cut-off points for urinary N-titin/Cr for distinguishing the greater-than-median and smaller-than-median reduction of muscle mass after 1 year. We enrolled 68 patients with interstitial lung disease. The median urinary N-titin/Cr value was 7.0 pmol/mg/dL. We observed significant negative correlations between urinary N-titin/Cr and changes in the PMCSA after 1 year (p < 0.001) and changes in the ESMCSA after 6 months (p < 0.001) and 1 year (p < 0.001). The cut-off points for urinary N-titin/Cr were 5.2 pmol/mg/dL and 10.4 pmol/mg/dL in the PMCSA and ESMCSA, respectively. In summary, urinary N-titin/Cr may predict muscle loss in the long-term and act as a clinically useful biomarker reflecting muscle damage. |
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言語 |
en |
書誌情報 |
en : Scientific Reports
巻 13,
号 1,
p. art. no. 9723,
発行日 2023-06-15
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出版者 |
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言語 |
en |
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出版者 |
Springer Nature |
ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-2322 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-023-36827-5 |
権利 |
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言語 |
en |
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権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2023 |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
引用 |
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内容記述タイプ |
Other |
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内容記述 |
Scientific Reports, 13(1), art. no. 9723; 2023 |
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言語 |
en |