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食餌制限モデルから見た老化制御メカニズム
http://hdl.handle.net/10069/0002000732
http://hdl.handle.net/10069/0002000732235cc576-b9ba-4e78-999b-6ca878eb6632
名前 / ファイル | ライセンス | アクション |
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YZ144_403.pdf (514 KB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2024-04-16 | |||||||
タイトル | ||||||||
言語 | ja | |||||||
タイトル | 食餌制限モデルから見た老化制御メカニズム | |||||||
言語 | ||||||||
言語 | jpn | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | longevity | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | dietary restriction | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Forkhead box O transcription factor | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | mitochondria | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
下川, 功
× 下川, 功
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著者別名 | ||||||||
姓名 | Shimokawa, Isao | |||||||
言語 | en | |||||||
その他のタイトル | ||||||||
その他のタイトル | Regulation of Aging Processes: A Perspective of Dietary Restriction Models | |||||||
言語 | en | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | The moderate restriction of dietary energy intake (dietary restriction: DR) extends the lifespan and health span of various laboratory animals, suggesting that it delays the aging process inherent in many animal species. Attenuated growth hormone and insulin-like growth factor-1 (IGF-1) signaling caused by mutations also increases the lifespan of mice, even those allowed to feed freely. In nematodes, the Daf16, mammalian Forkhead box O (FoxO) transcription factor, was shown to be required for lifespan extension in response to reduced IGF-1 signaling. Because DR also decreases the plasma concentration of IGF-1 in mammals, the IGF-1–FoxO axis may play a central role in the lifespan extension effect of DR and, thus, retardation of aging. Studies using knockout mice under DR conditions revealed the importance of FoxO1 and nuclear factor erythroid-derived 2-like 2 (Nrf2) in tumor suppression, and FoxO3 in lifespan extension. Human genomic studies also identified a strong association between a FOXO3 single nucleotide polymorphism and longevity. The aging mechanism is the most important risk factor for disease and frailty in aging humans. Therefore, further research on the application of DR to humans, the development of compounds and drugs that mimic the effects of DR, and mechanisms underlying FOXO3 polymorphisms for longevity is highly relevant to extending the human health span. | |||||||
言語 | en | |||||||
書誌情報 |
ja : YAKUGAKU ZASSHI en : Journal of the Pharmaceutical Society of Japan 巻 144, 号 4, p. 403-409, 発行日 2024-04-01 |
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出版者 | ||||||||
言語 | ja | |||||||
出版者 | 日本薬学会 | |||||||
出版者別言語 | ||||||||
en | ||||||||
The Pharmaceutical Society of Japan | ||||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0031-6903 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.1248/yakushi.23-00165-3 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | © 2024 The Pharmaceutical Society of Japan | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Yakugaku zasshi, 144(4), pp.403-409; 2024 | |||||||
言語 | en |