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Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice
http://hdl.handle.net/10069/0002000947
http://hdl.handle.net/10069/000200094714b0f3b5-2add-44af-b1e5-8da073fb87e9
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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公開日 | 2024-06-18 | |||||||||||||||||
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言語 | en | |||||||||||||||||
タイトル | Aspartame, as an artificial sweetener, does not affect renal function and antioxidative states in mice | |||||||||||||||||
言語 | ||||||||||||||||||
言語 | eng | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Aspartame | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Kidney | |||||||||||||||||
キーワード | ||||||||||||||||||
言語 | en | |||||||||||||||||
主題Scheme | Other | |||||||||||||||||
主題 | Food safety | |||||||||||||||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
資源タイプ | journal article | |||||||||||||||||
著者 |
Torigoe, Kenta
× Torigoe, Kenta
× Torigoe, Miki
× Oka, Satoru
× Obata, Yoko
× Mukae, Hiroshi
× Nishino, Tomoya
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内容記述タイプ | Abstract | |||||||||||||||||
内容記述 | Background and objective: Aspartame (L-aspartyl L-phenylalanine methyl ester) is an artificial sweetener widely used as a sugar substitute. There are concerns regarding the effects of high aspartame doses on the kidney owing to oxidative stress; however, whether the maximum allowed dose of aspartame in humans affects the kidneys remains unknown. Therefore, in this study, we investigated whether the maximum allowed dose of aspartame in humans affects the kidneys. Methods: In this study, animals were fed a folate-deficient diet to mimic human aspartame metabolism. Eight-week-old ICR mice were divided into control (CTL), 40 mg/kg/day of aspartame-administered (ASP), folate-deficient diet (FD), and 40 mg/kg/day of aspartame-administered with a folate-deficient diet (FD + ASP) groups. Aspartame was administered orally for eight weeks. Thereafter, we evaluated aspartame’s effect on kidneys via histological analysis. Results: There were no differences in serum creatinine and blood urea nitrogen levels between the CTL and ASP groups or between the FD and FD + ASP groups. There was no histological change in the kidneys in any group. The expression of superoxide dismutase and 4-hydroxy-2-nonenal in the kidney did not differ between the CTL and ASP groups or the FD and FD + ASP groups. Conclusion: Our findings indicate that the allowed doses of aspartame in humans may not affect kidney function or oxidative states. | |||||||||||||||||
言語 | en | |||||||||||||||||
書誌情報 |
en : BMC Research Notes 巻 17, 号 1, p. art. no. 155, 発行日 2024-06-05 |
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言語 | en | |||||||||||||||||
出版者 | BioMed Central Ltd | |||||||||||||||||
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収録物識別子タイプ | ISSN | |||||||||||||||||
収録物識別子 | 1756-0500 | |||||||||||||||||
DOI | ||||||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||
関連識別子 | 10.1186/s13104-024-06816-6 | |||||||||||||||||
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出版タイプ | VoR | |||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
引用 | ||||||||||||||||||
内容記述タイプ | Other | |||||||||||||||||
内容記述 | BMC Research Notes, 17, art. no.155; 2024 | |||||||||||||||||
言語 | en |