| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-14 |
| タイトル |
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|
タイトル |
Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
COVID-19 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
SARS-CoV-2 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immune complex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immune complexome analysis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Moriishi, Marino
Takazono, Takahiro
Hashizume, Junya
Aibara, Nozomi
Kutsuna, Yuki Jimbayashi
Okamoto, Masaki
Sawai, Toyomitsu
Hoshino, Teppei
Mori, Yusuke
Fukuda, Yuichi
Awaya, Yukikazu
Yamanashi, Hirotomo
Furusato, Yuichiro
Yanagihara, Toyoshi
Miyamoto, Hirotaka
Sato, Kayoko
Kodama, Yukinobu
Mizukami, Shusaku
Sakamoto, Noriho
Yamamoto, Kazuko
Sakamoto, Kei
Yanagihara, Katsunori
Izumikawa, Koichi
Maeda, Takahiro
Nakashima, Mikiro
Fukushima, Kiyoyasu
Mukae, Hiroshi
Ohyama, Kaname
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The factors contributing to the development of severe coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. Although the presence of immune complexes (ICs), formed between antibodies and their antigens, has been linked to COVID-19 severity, their role requires further investigation, and the antigens within these ICs are yet to be characterized. Method: Here, a C1q enzyme-liked immunosorbent assay and immune complexome analysis were used to determine IC concentrations and characterize IC antigens, respectively, in the sera of 64 unvaccinated COVID-19 patients with PCR-confirmed SARS-CoV-2 infection, enrolled at seven participating centers in 2020. For the analysis, the patients were split into the severe (n = 35) and non-severe (n = 28) groups on the basis of their COVID-19 symptoms. Results: We found that neither serum IC concentration nor IC antigen number was associated with COVID-19 severity. However, we identified six IC antigens, which were significantly enriched in the severe versus non-severe group. These IC antigens were all derived from human proteins, namely haptoglobin, the serum amyloid A-2 protein, the serum amyloid A-1 protein, clusterin, and lipopolysaccharide-binding protein, and complement-factor-H-related protein 3. Meanwhile, we found no association between COVID-19 severity and IC antigens derived from SARS-CoV-2 proteins. Collectively, the six IC antigens predicted COVID-19 severity with a moderate degree of accuracy (area under the receiver operating characteristic curve = 0.90, sensitivity = 94 %, specificity = 79 %). Conclusions: The IC antigen signature identified in this study may have important implications for the diagnosis and treatment of severe COVID-19. |
|
言語 |
en |
| 書誌情報 |
en : Clinical Biochemistry
巻 135,
p. art. no. 110865,
発行日 2024-12-20
|
| 出版者 |
|
|
出版者 |
Elsevier Inc. |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00099120 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.clinbiochem.2024.110865 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Clinical Biochemistry, 135, art. no. 110865; 2024 |
|
言語 |
en |
CB135_110865.pdf (1.2 MB)
