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Preoperative Serum Levels of Sialyl Lewisa, Sialyl Lewisx, and Carcinoembryonic Antigens as Prognostic Factors after Resection for Primary Breast Cancer
http://hdl.handle.net/10069/16206
http://hdl.handle.net/10069/16206d5b08b42-f5e4-418b-ae6d-171259c00f41
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta47_01_06_t.pdf (562.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-13 | |||||
| タイトル | ||||||
| タイトル | Preoperative Serum Levels of Sialyl Lewisa, Sialyl Lewisx, and Carcinoembryonic Antigens as Prognostic Factors after Resection for Primary Breast Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | carcinoembryonic antigen | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CEA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sialyl Lewisa | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CA 19-9 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sialyl LewisX | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CSLEX 1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | breast cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prognostic value | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Nakagoe, Tohru
× Nakagoe, Tohru× Itoyanagi, Noriaki× Ikuta, Yasushi× Ayabe, Hiroyoshi× Hara, Shinsuke× Ishikawa, Hiroshi× Minami, Hiroyuki× Fukushima, Kiyoyasu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Sialyl Lewisa (CA19-9) and sialyl LewisX antigens (CSLEXI) may play a role in tumor metastasis by serving as functional ligands in the cell adhesion system. To determine their prognostic value, we examined preoperative serum levels of CA19-9, CSLEXI, and carcinoembryonic antigen (CEA) in 64 female patients with primary breast cancer who underwent radical mastectomy. The patients were divided into two groups, termed the low- and high-antigen groups based on a value selected as a diagnostic cut-off. Correlation between the serum antigen levels, various established clinicopathologic factors, and prognosis were studied by univariate and multivariate analysis. The high- CEA group was at a more advanced stage (including T factor, N factor, M factor, and Stage) than the low-CEA group. Patients with high serum levels of CEA had shorter disease- specific intervals than those with low serum levels (P <0.0001), whereas disease-specific intervals did not differ between low- and high-CA19-9 or CSLEXI groups. A Cox's regression multivariate analysis revealed a high serum CEA level as an independent factor for worse outcome, separate from Stage. In conclusion, an elevated preoperative serum CEA level was a predictor for poor outcome after radical mastectomy for breast cancer, while CA19-9 and CSLEX1 were not. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 47, 号 1-2, p. 37-41, 発行日 2002-06-18 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| sortkey | ||||||
| 値 | P00037-P00041 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia. 2002, 47(1-2), p.37-41 | |||||
