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Elevated Expression of Poly(ADP-Ribose) Polymerase-1 is Associated with Liver Metastasis in Colorectal Cancer.
http://hdl.handle.net/10069/16220
http://hdl.handle.net/10069/16220108b2044-43fc-4225-ae65-fa4cf4a49607
名前 / ファイル | ライセンス | アクション |
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acta47_03_05_t.pdf (6.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Elevated Expression of Poly(ADP-Ribose) Polymerase-1 is Associated with Liver Metastasis in Colorectal Cancer. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | poly(ADP-ribose) polymerase-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | poly (ADP-ribose) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | p53 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | colorectal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver metastasis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yano, Hiroshi
× Yano, Hiroshi× Tsuji, Takashi× Haseba, Masatoshi× Komatsu, Hideaki× Hidaka, Shigekazu× Sawai, Terumitsu× Yamaguchi, Hiroyuki× Yasutake, Toru× Nakagoe, Tohru× Tagawa, Yutaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Activation of poly(ADP-ribose) polymerase-1 (PARP-1) and its subsequent cleavage are early markers of apoptosis. PARP-1 is associated with DNA repair and so chromosome stability, cell cycle regulation, as well as tumorigenesis. To investigate the role of PARP-1 expression in colorectal carcinoma and its metastasis of liver, we compared the expression of PARP-1 in primary colorectal cancers with (n=15) and without liver metastasis (n=17) using a semi-quantitative reverse transcription - polymerase chain reaction. We also examined the expressions of poly(ADP-ribose) (PAR) and p53 in these tumors by immunohistochemistry. A significantly higher PARP-1 mRNA expression was noted in tumors with liver metastasis than those without liver metastasis (p<0.01). Colorectal cancers positively stained for p53 exhibited significantly higher PARP-1 mRNA expression than p53-negative tumors (p<0.01). The PAR labeling index (LI) of tumors with metastasis (0.33 ツア 0.33) was not significantly different (p=0.35) from that of tumors without liver metastasis (0.38 ツア 0.19). p53-positive tumors tended to have higher PAR LI levels than p53-negative tumors (p=0.08). Our findings suggest that PARP-1 may contribute to liver metastasis due to its DNA repair activity, resulting in survival of the tumor cells with accumulation of metastaticrelated gene's damages. Detailed analysis of PARP-1 may be useful in cancer research and/or cancer therapy. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 47, 号 3-4, p. 111-115, 発行日 2002-12-17 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00111-P00115 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2002, 47(3-4), p.111-115 |