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Lambert?Eaton myasthenic syndrome: Clinical review
http://hdl.handle.net/10069/37240
http://hdl.handle.net/10069/37240304997a6-1473-40a4-90a1-651083fc78a0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CEN7_238.pdf (609.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2017-05-09 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Lambert?Eaton myasthenic syndrome: Clinical review | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Lambert?Eaton myasthenic syndrome | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | P/Q-type voltage-gated calcium channel | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | paraneoplastic neurological syndrome | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | small cell lung cancer | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Motomura, Masakatsu
× Motomura, Masakatsu
× Nakata, Ruka
× Shiraishi, Hirokazu
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Lambert?Eaton myasthenic syndrome (LEMS) is an autoimmune disease of the neuromuscular junction and approximately 60% of LEMS patients have a tumor, mostly small cell lung cancer, as a paraneoplastic neurological syndrome. LEMS patients develop a unique set of clinical characteristics, which include proximal muscle weakness, depressed tendon reflexes with post-tetanic potentiation and autonomic symptoms. Interestingly, slightly <10% of LEMS patients have cerebellar ataxia (LEMS with paraneoplastic cerebellar degeneration). Considering its pathomechanism, LEMS is a presynaptic disorder of neuromuscular transmission in which quantal release of acetylcholine is impaired by autoantibodies for P/Q-type voltage-gated calcium channels at active zones, although an animal model by immunizing purified P/Q-type voltage-gated calcium channels has not yet been successful. | |||||||||||
| 書誌情報 |
Clinical and Experimental Neuroimmunology 巻 7, 号 3, p. 238-245, 発行日 2016-08 |
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| 出版者 | ||||||||||||
| 出版者 | 日本神経免疫学会 | |||||||||||
| 出版者別言語 | ||||||||||||
| Japanese Society for Neuroimmunology | ||||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 17591961 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1111/cen3.12326 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | c 2016 Japanese Society for Neuroimmunology | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 引用 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | Clinical and Experimental Neuroimmunology, 7(3), pp.238-245; 2016 | |||||||||||
