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Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients
http://hdl.handle.net/10069/37342
http://hdl.handle.net/10069/373429ba88da9-88bc-4274-8e49-1f1fde32928b
名前 / ファイル | ライセンス | アクション |
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EBioMed12_150.pdf (818.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-19 | |||||
タイトル | ||||||
タイトル | Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Creutzfeldt-Jakob disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-neural tissue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prion-seeding activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SD50 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takatsuki, Hanae
× Takatsuki, Hanae× Fuse, Takayuki× Nakagaki, Takehiro× Mori, Tsuyoshi× Mihara, Ban× Takao, Masaki× Iwasaki, Yasushi× Yoshida, Mari× Murayama, Shigeo× Atarashi, Ryuichiro× Nishida, Noriyuki× Satoh, Katsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human prion diseases are neurodegenerative disorders caused by abnormally folded prion proteins in the central nervous system. These proteins can be detected using the quaking-induced conversion assay. Compared with other bioassays, this assay is extremely sensitive and was used in the present study to determine prion distribution in sporadic Creutzfeldt-Jakob disease patients at autopsy. Although infectivity of the sporadic form is thought to be restricted within the central nervous system, results showed that prion-seeding activities reach 106/g from a 50% seeding dose in non-neuronal tissues, suggesting that prion-seeding activity exists in non-neural organs, and we suggested that non-neural tissues of 106/g SD50 did not exist the infectivity. | |||||
書誌情報 |
EBioMedicine 巻 12, p. 150-155, 発行日 2016-10 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 23523964 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ebiom.2016.08.033 | |||||
権利 | ||||||
権利情報 | c 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | EBioMedicine, 12, pp.150-155; 2016 |