WEKO3
アイテム
Insulin as the "Primary" Autoantigen in Type 1 Diabetes?
http://hdl.handle.net/10069/9257
http://hdl.handle.net/10069/9257bec0d4c0-0633-4ee0-b278-ffc82f58923f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta49_01_01.pdf (1.2 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-11-02 | |||||
| タイトル | ||||||
| タイトル | Insulin as the "Primary" Autoantigen in Type 1 Diabetes? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Type1diabetes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NODmouse | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Insulingene | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Insulinautoantibody | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | InsulinBchainpeptide | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Abiru, Norio
× Abiru, Norio |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Type 1 diabetes of both the human and NOD mouse is associated with autoimmunity directed against insulin which is the only β cell specific autoantigen. Variable number of tandem repeats in the 5′ region of insulin gene on chromosome 11 is associated with the risk of type 1 diabetes in human. Mice have two insulin genes including the insulin 1 gene (chromsome 19) and the insulin 2 gene (chromsome 7). The insulin 2 gene knockout when bred onto NOD mice accelerates diabetes. In contrast to insulin 2, diabetes and insulitis were markedly reduced in insulin 1 knockout mice with decreased and delayed diabetes. Autoantibodies to insulin can predict diabetes in man and NOD mice. Insulin peptides can be used to induce insulitis and diabetes in non-diabetic strain mice. Our results suggest that insulin molecule is a possible "primary" autoantigen that initiates a pathogenesis of type 1 diabetes. An administration of insulin or its peptide can prevent the development of diabetes in NOD mice but we cannot at present safely prevent type 1 diabetes in humans. A series of clinical trials are under way and planned. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 49, 号 1-2, p. 1-6, 発行日 2004-06 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関係URI | ||||||
| 関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/49.1 | |||||
| sortkey | ||||||
| 値 | P00001-P00006 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia. 2004, 49(1-2), p.1-6 | |||||
