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Regulation and Functions of Clusterin: A Protector Against Stress
http://hdl.handle.net/10069/9313
http://hdl.handle.net/10069/93133e4baa5a-b42e-4e46-b610-8228ce4e7912
名前 / ファイル | ライセンス | アクション |
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acta50_s1_55.pdf (693.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Regulation and Functions of Clusterin: A Protector Against Stress | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clusterin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stressresponse | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Criswell, Tracy
× Criswell, Tracy× A.Boothman, David |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Radiation therapy is a common treatment for many types of tumors. Therefore, it is vital to understand the cellular responses to radiotherapy in malignant cells, as well as the surrounding normal tissues in order to optimize antitumor efficacy. Clusterin (CLU) is a secreted glycoprotein that has been implicated in many normal biological processes as well as many pathological diseases, including cancer. Our laboratory identified the secreted form of clusterin (sCLU) as a protein/transcript that could be induced by doses of ionizing radiation (IR) as low as 0.02 Gy, suggesting a role for sCLU in the cellular response to IR. While the exact functions of CLU are complex, it has been suggested that sCLU, the fully processed and glycosylated form of the CLU protein, plays a role in cytoprotection after cellular stress. sCLU appears to provide cytoprotection against cellular injury and inflammatory responses potentially by acting as a molecular chaperone, clearing cellular debris or binding to inflammatory and growth suppressive cytokines, such as TGF-?1. A better understanding of this protein and its various roles in cellular responses to stress will allow us to generate better treatments and therapies for many different pathological processes. The functions of sCLU and its role(s) in disease processes will be discussed. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 50, 号 supl.1, p. 55-62, 発行日 2005-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.S55 | |||||
sortkey | ||||||
P00055-P00062 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2005, 50(supl.1), p.55-62 |