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Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer
http://hdl.handle.net/10069/9318
http://hdl.handle.net/10069/93180fbbb492-6455-4b5e-bd2e-8635a4229161
名前 / ファイル | ライセンス | アクション |
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acta50_s1_87.pdf (432.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thyroidcancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Segmentaljumpingtranslocation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ret | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakashima, Masahiro
× Nakashima, Masahiro× Takamura, Noboru× Namba, Hiroyuki× Saenko, Vladimir× Hayashi, Tomayoshi× Sekine, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Radiation etiology is well known in thyroid carcinogenesis. Ret rearrangement is the commonest oncogenic alterations in Chernobyl-related papillary thyroid cancer (PTC). To evaluate whether there is a radiation signature, we analyzed Ret rearrangement in radiation-associated thyroid cancers with fluorescence in situ hybridization (FISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). The FISH analysis demonstrated segmental jumping translocation (SJT) of Ret gene in radiation-associated thyroid cancers but not in sporadic well differentiated PTC. Furthermore, Ret SJT was commonly observed in anaplastic thyroid cancer (ATC) including both radiation-associated and sporadic cancers. In PTC, Ret SJT was restricted to radiation-associated or high-grade cases. Because Ret SJT was not observed in sporadic, well differentiated and low-grade cases of PTC, Ret SJT might be a molecular marker for radiation-induced and/or aggressive cases of PTC. SJTs are unbalanced translocations involving a donor chromosome arm or chromosome segment that has fused to multiple recipient chromosome, and mainly reported in treatment-related leukemias, while very rare in solid cancers. We found SJT in radiation-induced and high-grade thyroid cancers, suggesting chromosomal instability. This is the first report showing SJT in thyroid cancer, and probably the third report showing SJT in solid cancer in vivo. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 50, 号 supl.1, p. 87-89, 発行日 2005-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.S87 | |||||
sortkey | ||||||
P00087-P00089 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2005, 50(supl.1), p.87-89 |