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Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats
http://hdl.handle.net/10069/9325
http://hdl.handle.net/10069/932587ec86b7-2cc8-4933-ac07-ac8848b0f0c4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta50_01_29.pdf (191.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-11-02 | |||||
| タイトル | ||||||
| タイトル | Phosphodiesterase V Inhibitors Dilate the Pulmonary Artery of Monocrotaline-Induced Pulmonary Hypertensive Rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PDEVinhibitor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Monocrotaline | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pulmonaryhypertension | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Makita, Tetsuji
× Makita, Tetsuji× Tsutsumi, Yohsuke× Cho, Sungsam× Shibata, Osamu× Sumikawa, Koji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Treatment of pulmonary hypertension has not yet been established and effective drug therapies are required. We hypothesized that inhibition of cyclic guanosine monophoshate (cGMP)- phosphodiesterase (PDE) would result in specific vasodilation of the hypertensive pulmonary arteries. This study was carried out to determine whether PDE V inhibitors could dilate pulmonary artery (PA) from monocrotaline-induced pulmonary hypertensive rats. Thirty-six Wistar rats were given either monocrotaline (105 mg/kg) or normal saline (control) subcutaneously. Three weeks later, the PA rings were isolated and mounted in 5-mL organ chambers. After precontraction with norepinephrine (0.1 μmM), one of two PDE V inhibitors, zaprinast and dipyridamole, was added in a cumulative fashion. We also investigated whether nitric oxide synthetase (NOS) inhibitor modifies the effects of the PDE V inhibitors on the PA. Zaprinast and dipyridamole dose-dependently dilated the PA from either saline- or monocrotaline- treated rats. There was no difference in the dilatory effect between monocrotaline and saline rats. Pretreatment of a NOS inhibitor (NG-nitro-L-arginine methyl ester (0.1 mM)) reduced moderately the vasodilatory effect of zaprinast on the PA from monocrotaline-treated but not saline-treated rats. The results suggest that PDE V inhibitors exert a strong vasodilating effect on PA of pulmonary hypertensive rats as well as on that of normal rats, and that NO plays a role, at least in part, in the effect of PDE V inhibition on PA of pulmonary hypertensive rats. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 50, 号 1, p. 29-33, 発行日 2005-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関係URI | ||||||
| 関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.29 | |||||
| sortkey | ||||||
| 値 | P00029-P00033 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia. 2005, 50(1), p.29-33 | |||||
