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Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation
http://hdl.handle.net/10069/00040525
http://hdl.handle.net/10069/000405251e9c6ad9-d809-41a9-8902-25465c272871
名前 / ファイル | ライセンス | アクション |
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OncLet21_251.pdf (4.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-02 | |||||
タイトル | ||||||
タイトル | Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dipyridamole | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Doxorubicin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human colorectal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stem cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Abdelghany, Lina
× Abdelghany, Lina× El-Μahdy, Nageh× Kawabata, Tsuyoshi× Goto, Shinji× Li, Tao-Sheng |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dipyridamole, a traditional anti-platelet drug, has been reported to inhibit the proliferation of cancer cells. The present study aimed to investigate the possibility of dipyridamole as an adjuvant of chemotherapy by enhancing the cytotoxicity of an anti-cancer drug. The cytotoxicity of colorectal cancer cells (HCT-8), CD133+/CD44+ stem-like subpopulation of HCT-8 cells and lymphoma cells (U937) to dipyridamole and/or doxorubicin was evaluated using MTT proliferation and colony forming assays. The expression levels of phosphorylated cAMP-regulatory element-binding protein (pCREB) and poly(ADP-ribose) polymerase-1 (PARP-1) in cells were analyzed via western blotting and immunofluores- cence. The present study reported controversial data regarding the anti-cancer effect of dipyridamole. Dipyridamole increased, rather than inhibited, the proliferation of HCT-8 and U937 cells in a dose-dependent manner. Furthermore, it was found that dipyridamole significantly increased the expression levels of pCREB and PARP-1. However, the combined usage of dipyridamole significantly enhanced the cytotoxicity of doxorubicin to HCT-8 cells at particular doses. Based on the current findings, dipyridamole likely induces the phosphoryla- tion of CREB to promote the proliferation of cancer cells, but may enhance the cytotoxicity of anti-cancer drugs at particular doses. | |||||
書誌情報 |
Oncology Letters 巻 21, 号 4, p. 251, 発行日 2021-02-03 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1792-1074 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ol.2021.12512 | |||||
権利 | ||||||
権利情報 | © Abdelghany et al. This is an open access article distributed under the terms of Creative Commons Attribution License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncology Letters, 21(4), art.no.251; 2021 |