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Significance of serum palmitoleic acid levels in inflammatory bowel disease
http://hdl.handle.net/10069/00041042
http://hdl.handle.net/10069/0004104291edaa99-9a0f-4daf-91a4-1c1c2d383ad2
名前 / ファイル | ライセンス | アクション |
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SciRep11_16260.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-19 | |||||
タイトル | ||||||
タイトル | Significance of serum palmitoleic acid levels in inflammatory bowel disease | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Akazawa, Yuko
× Akazawa, Yuko× Morisaki, Tomohito× Fukuda, Hiroko× Norimatsu, Kiyuu× Shiota, Junya× Hashiguchi, Keiichi× Tabuchi, Maiko× Kitayama, Moto× Matsushima, Kayoko× Yamaguchi, Naoyuki× Kondo, Hisayoshi× Fujita, Fumihiko× Takeshita, Hiroaki× Nakao, Kazuhiko× Takeshima, Fuminao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficial. Palmitoleic acid (PO) is an adipose tissue-derived mono-unsaturated free fatty acid that potentially serves as a lipokine in metabolic and inflammatory diseases. The aim of this study was to investigate the significance of PO levels in the serum of patients with UC and CD. The study included patients with UC (n = 22), patients with CD (n = 35), and controls (n = 22). The levels of serum PO were analyzed using gas chromatography. The association of serum PO levels with the clinical features and disease outcomes in IBD was examined. Serum PO levels were significantly higher in patients with CD than in controls, whereas no difference in these levels was observed between patients with UC and controls. Serum PO levels were significantly associated with the CD activity index. Additionally, high serum PO levels were associated with an increased risk of surgical intervention requirement during follow-up. In a pilot study with a few patients, high PO levels were observed in the mesenteric tissue in the active disease site of patients with CD (n = 7) compared with those with colon cancer (n = 6). Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD. | |||||
書誌情報 |
Scientific Reports 巻 11, p. 16260, 発行日 2021-08-10 |
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出版者 | Springer Nature | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-021-95923-6 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scientific Reports, 11, art. no. 16260; 2021 |