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Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters
http://hdl.handle.net/10069/00041167
http://hdl.handle.net/10069/00041167de3f4ce6-f65e-4fd2-a2d7-5c13e4252996
名前 / ファイル | ライセンス | アクション |
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SciRep11_21259.pdf (2.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-01-20 | |||||
タイトル | ||||||
タイトル | Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kinoshita, Takaaki
× Kinoshita, Takaaki× Watanabe, Kenichi× Sakurai, Yasuteru× Nishi, Kodai× Yoshikawa, Rokusuke× Yasuda, Jiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern worldwide. Notably, co-infection with other pathogens may worsen the severity of COVID-19 symptoms and increase fatality. Here, we show that co-infection with influenza A virus (IAV) causes more severe body weight loss and more severe and prolonged pneumonia in SARS-CoV-2-infected hamsters. Each virus can efficiently spread in the lungs without interference by the other. However, in immunohistochemical analyses, SARS-CoV-2 and IAV were not detected at the same sites in the respiratory organs of co-infected hamsters, suggesting that either the two viruses may have different cell tropisms in vivo or each virus may inhibit the infection and/or growth of the other within a cell or adjacent areas in the organs. Furthermore, a significant increase in IL-6 was detected in the sera of hamsters co-infected with SARS-CoV-2 and IAV at 7 and 10 days post-infection, suggesting that IL-6 may be involved in the increased severity of pneumonia. Our results strongly suggest that IAV co-infection with SARS-CoV-2 can have serious health risks and increased caution should be applied in such cases. | |||||
書誌情報 |
Scientific Reports 巻 11, 号 1, p. art. no. 21259, 発行日 2021-10-28 |
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出版者 | Springer Nature | |||||
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収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
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関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-021-00809-2 | |||||
権利 | ||||||
権利情報 | © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licen ses/by/4.0/. | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Scientific Reports, 11(1), art. no. 21259; 2021 |