| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2022-02-25 |
| タイトル |
|
|
タイトル |
Evaluation of olfactory impairment using a simple test kit “The Odor Stick Identification test for the Japanese” (OSIT-J) in neurodegenerative diseases |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Odor identification |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
OSIT-J |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Alzheimer's disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Dementia with Lewy bodies |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
amnestic mild cognitive impairment |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
REM sleep behavior disorder |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Parkinson's disease |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
Yokogi, Maiko
Kusano, Kayoko
Matsubara, Rie
Sato, Maki
Tomita, Itsuro
Seto, Makiko
Satoh, Akira
Tsujihata, Mitsuhiro
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Olfactory deficit has been studied in aging, amnestic mild cognitive impairment (aMCI), Alzheimer’s disease (AD). Parkinson's disease (PD), dementia with Lewy bodies (DLB) and idiopathic REM-sleep behavior disorder (iRBD). Our aim was to investigate the usefulness of a simple test kit “The Odor Stick Identification test for the Japanese ”(OSIT-J) in clinical practice.
Methods: A total of 240 patients were enrolled in this study, including 44 cognitively normal subjects (NS), 31 patients with aMCI, 70 patients with mild AD (AD-mild), 28 patients with DLB, 31 patients with PD and 36 patients with iRBD. The OSIT-J consists of 12 types of odor sticks. The subjects were asked to select an odor from a list of 4 odors that were rubbed on the medicine wraping paper for each odor stick. The maximum score was 12.
Results: The mean odor identification (OI) score decreased in the order of aMCI, iRBD, AD-mild, PD and DLB (NS: aMCI, P<0.05, NS: AD-mild, DLB, PD and iRBD, P<0.001, aMCI: DLB, P<0.001, aMCI: PD, P<0.01 (Kruskal-Wallis, Dunn’s test). The sensitivity and specificity in differentiating each disease from NS at a cutoff value of 8 was 96.8% and 79.5%, respectively, in PD, and 96.4% and 79.5% in DLB. An ageing effect was observed in NSs ( r=-0.453 (p<0.01)).
Conclusions: Olfactory deficit is a non-specific phenomenon. However, it is important to be aware of the underlying diseases or future development of diseases. The OSIT-J, which is a simple test, is useful for detecting OI abnormalities in daily clinical practice. |
| 書誌情報 |
Acta medica Nagasakiensia
巻 65,
号 2,
p. 29-36,
発行日 2022-01
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00016055 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00508430 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
Nagasaki University School of Medicine |
| 出版者別言語 |
|
|
|
長崎大学医学部 |
| sortkey |
|
|
|
01 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Acta medica Nagasakiensia, 65(2), pp.29-36; 2022 |
ActMed65_29.pdf (672.9 kB)
