WEKO3
アイテム
Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells
http://hdl.handle.net/10069/00042139
http://hdl.handle.net/10069/0004213900eafcfc-f126-4d92-a460-2528e041e212
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BPB46_446.pdf (1.3 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-03-24 | |||||
| タイトル | ||||||
| タイトル | Enhancement of Neprilysin Activity by Natural Polyphenolic Compounds and Their Derivatives in Cultured Neuroglioma Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neprilysin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | flavone | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polyphenol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | aliphatic derivative | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Alzheimer’s disease | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hori, Yuma
× Hori, Yuma× Watanabe, Kaori× Yassen, Asmaa S. A.× Shirotani, Keiro× Tanaka, Takashi× Iwata, Nobuhisa |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The onset of Alzheimer’s disease (AD) is characterized by accumulation of amyloid β peptide (Aβ) in the brain. Neprilysin (NEP) is one of the major Aβ-degrading enzymes. Given findings that NEP expression in the brain declines from the early stage of AD before apparent neuronal losses are observed, enhancement of NEP activity and expression may be a preventive and therapeutic strategy relevant to disease onset. We screened for compounds that could enhance the activity and expression of NEP using a polyphenol library previously constructed by our research group and investigated the structure–activity relationships of the identified polyphenols. We found that amentoflavone, apigenin, kaempferol, and chrysin enhanced the activity and expression of NEP, suggesting that chemical structures involving a double bond between positions 2 and 3 in the C ring of flavones are important for NEP enhancement, while catechol or pyrogallol structures, except for the galloyl group of catechins, abolished these effects. Moreover, natural compounds, such as quercetin, were not effective per se, but were changed to effective compounds by adding a lipophilic moiety. Using our study findings, we propose improvements for dietary habits with experimental evidence, and provide a basis for the development of novel small molecules as disease-modifying drugs for AD. | |||||
| 書誌情報 |
Biological and Pharmaceutical Bulletin 巻 46, 号 3, p. 446-454, 発行日 2023-03-01 |
|||||
| 出版者 | ||||||
| 出版者 | Pharmaceutical Society of Japan | |||||
| 出版者別言語 | ||||||
| 値 | 日本薬学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0918-6158 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/bpb.b22-00833 | |||||
| 権利 | ||||||
| 権利情報 | © 2023 The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Biological & pharmaceutical bulletin, 46(3), pp. 446-454; 2023 | |||||
