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Increased levels of cell-free miR-517a and decreased levels of cell-free miR-518b in maternal plasma samples from placenta previa pregnancies at 32 weeks gestation
http://hdl.handle.net/10069/36213
http://hdl.handle.net/10069/36213ae97e8b3-f997-48ef-9cfd-878f4a50ad0b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYO42_Hasegawa.pdf (397.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-03-15 | |||||
| タイトル | ||||||
| タイトル | Increased levels of cell-free miR-517a and decreased levels of cell-free miR-518b in maternal plasma samples from placenta previa pregnancies at 32 weeks gestation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pregnancy-associated microRNA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | maternal plasma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | placenta previa | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | alert bleeding | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hemorrhage | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
長谷川, ゆり
× 長谷川, ゆり |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115208 | |||||
| 姓名 | Hasegawa, Yuri | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: The aim of this study was to clarify the association between placenta previa and circulating levels of cell-free pregnancy-associated placenta-specific microRNAs (miRNAs) in maternal plasma. Method: Twenty singleton pregnancies with placenta previa (placenta previa group) and 26 uncomplicated pregnancies (control group) were recruited. Blood sampling was performed at 32 weeks of gestation, and cesarean delivery in all cases of placenta previa was performed at a mean gestational age of 37 weeks. The maternal plasma concentrations of cell-free pregnancy-associated placenta-specific miRNAs (miR-517a and miR-518b) were measured by absolute quantitative real-time reverse transcription-polymerase chain reaction. Results: Plasma concentrations of cell-free miR-517a were significantly higher in the placenta previa group than that in the control group (P = .011), while the plasma concentration of cell-free miR-518b was significantly lower in the placenta previa group than that in the control group (P = .004). Plasma concentrations of cell-free miR-517a in placenta previa were significantly higher in placenta previa with alert bleeding later group than those in placenta previa without alert bleeding group or control group (P = .030 or .047, respectively) and correlated with the volume of hemorrhage at delivery (R and P value: .512 and .025). Conclusion: Plasma concentrations of cell-free miR-517a and miR-518b at 32 weeks of gestation were altered in pregnant women with placenta previa, and the circulating level of cell- free miR-517a in placenta previa may be a predictive marker for the risks of alert bleeding later and massive hemorrhage at delivery. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)乙第42号 学位授与年月日:平成28年2月3日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Yuri Hasegawa, Kiyonori Miura, Ai Higashijima, Shuhei Abe, Shoko Miura, Koh-ichiro Yoshiura, Hideaki Masuzaki | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Reproductive Sciences, 22(12), pp.1569-1576; 2015 | |||||
| 書誌情報 |
Reproductive Sciences 巻 22, 号 12, p. 1569-1576, 発行日 2016-02-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1933-7191 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1933-7205 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1177/1933719115589407 | |||||
| 権利 | ||||||
| 権利情報 | (C)2015, Society for Reproductive Investigation. | |||||
| 権利 | ||||||
| 権利情報 | The final, definitive version of this paper has been published in Reproductive Sciences, Vol.22(12), December 2015 by SAGE Publications Ltd, All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 前置胎盤合併妊婦では妊娠32週における母体血漿中miR-517aは増加し、miR-518bは減少する | |||||
| 出版者 | ||||||
| 出版者 | Sage | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-02-03 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 乙医歯薬第42号 | |||||
| 学位の種類 | ||||||
| 値 | 論文博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2016-02-03) | |||||
