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Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites
http://hdl.handle.net/10069/37062
http://hdl.handle.net/10069/37062c5f8c3fb-8240-44d8-a3fd-5a1e5eb3d4e3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK859_Doe.pdf (742.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-01 | |||||
| タイトル | ||||||
| タイトル | Expression of PD-1/LAG-3 and cytokine production by CD4+T cells during infection with Plasmodiumparasites | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | malaria | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD4+ T cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | inhibitory receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytokines | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Doe, Henrietta Terko
× Doe, Henrietta Terko |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115271 | |||||
| 姓名 | ドー, ヘンリータ テーコ | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CD4+ T cells play critical roles in protection against the blood-stage of malaria infection, but their uncontrolled activation can be harmful to the host. We compared the expression of inhibitory receptors on activated CD4+ T cells and their cytokine production using rodent models of Plasmodium parasites, and compared them with those from a bacterial and another protozoan infection. CD4+ T cells from mice infected with P. yoelii 17XL, P yoelii 17XNL, P. chabaudi, P. vinckei, and P. berghei expressed the inhibitory receptors, PD-1 and LAG-3 as early as 6 days after infection, while those from either Listeria monocytogenes or Leishmania major-infected mice did not. In response to T-cell receptor stimulation, CD4+ T cells from mice infected with all the pathogens under study produced high levels of IFN-γ. IL-2 production was reduced in mice infected with Plasmodium species, but not with Listeria or Leishmania. In vitro blockade of the interaction between PD-1 and its ligands resulted in increased IFN-γ production in response to Plasmodium antigens, implying that PD-1 expressed on activated CD4+ T cells actively inhibit T cell immune responses. Studies using Myd88-/-, Trif-/-, and Irf3-/- mice showed that the induction of these CD4+ T cells and their ability to produce cytokines was largely independent of toll-like receptor signaling. These studies suggest that the expression of the inhibitory receptors, PD-1 and LAG-3 on CD4+ T cells and their reduced IL-2 production are common characteristic features of Plasmodium infection. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第859号 学位授与年月日:平成28年3月18日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Henrietta T. Doe, Daisuke Kimura, Mana Miyakoda, Kazumi Kimura, Masoud Akbari, Katsuyuki Yui | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Microbiology and Immunology, 60(2), pp.121-131; 2016 | |||||
| 書誌情報 |
Microbiology and Immunology 巻 60, 号 2, p. 121-131, 発行日 2016-03-18 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03855600 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/1348-0421.12354 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2015 the Japanese Society for Bacteriology, the Japanese Society for Virology, the Japanese Society for Host Defense Research, and John Wiley & Sons Australia, Ltd. | |||||
| 権利 | ||||||
| 権利情報 | This is the peer reviewed version of the following article: Microbiology and Immunology, 60(2), pp.121-131; 2016, which has been published in final form at http://dx.doi.org/10.1111/1348-0421.12354. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | マラリア原虫感染におけるCD４＋T細胞のPD-1／LAG-3発現とサイトカイン産生の解析 | |||||
| 出版者 | ||||||
| 出版者 | John Wiley & Sons Australia, Ltd | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2016-03-18 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第859号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2016-03-18) | |||||
