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Efficacy of freeze-dried platelet-rich plasma in bone engineering
http://hdl.handle.net/10069/37042
http://hdl.handle.net/10069/37042eb127b20-14eb-49a6-8025-9df9976bbb3d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK913_Nakatani.pdf (2.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-02-06 | |||||
| タイトル | ||||||
| タイトル | Efficacy of freeze-dried platelet-rich plasma in bone engineering | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Platelet-rich plasma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Freeze-Dry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Long storage | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Super-concentrated platelets | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bone regeneration | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
中谷, 佑哉
× 中谷, 佑哉 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115521 | |||||
| 姓名 | Nakatani, Yuya | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Platelet-rich plasma (PRP) is typically isolated and applied immediately after preparation, making it both a time- and labor-intensive addition to the operative procedure. Thus, it would be convenient if PRP could be preserved. We evaluated the efficacy of freeze-dried PRP (FD-PRP), as compared with freshly isolated PRP (f-PRP) for bone engineering. Design: FD-PRP was prepared by lyophilization of f-PRP and was subsequently preserved at ?20 °C for one month. It was then rehydrated with an equal or 1/3 amount of distilled water (×1FD-PRP, ×3FD-PRP, respectively), and we assessed its gelation properties and the release of growth factors (PDGF-BB, TGF-β1, and VEGF). We also examined the bone forming ability with onlay-grafting on mice calvaria using β-TCP granules as a scaffold. Results: FD-PRP showed comparable gelation as f-PRP. In terms of growth factor release, × 1FD-PRP released identical concentrations of PDGF-BB and TGF-β1 to f-PRP, while ×3FD-PRP released approximately 3-fold concentrations when compared with f-PRP. In vivo, ×1FD-PRP promoted identical levels of the bone formation as f-PRP, and ×3FD-PRP induced more abundant bone formation. Conclusions: These results suggest that f-PRP can be stored without functional loss by freeze-drying and the concentration of PRP may improve its efficacy in bone engineering. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第913号 学位授与年月日:平成29年2月1日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Yuya Nakatani, Hideki Agata, Yoshinori Sumita, Takamitsu Koga, Izumi Asahina | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Archives of Oral Biology, 73, pp.172-178; 2017 | |||||
| 書誌情報 |
Archives of Oral Biology 巻 73, p. 172-178, 発行日 2017-02-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00039969 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.archoralbio.2016.10.006 | |||||
| 権利 | ||||||
| 権利情報 | c 2016 Elsevier Ltd. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | フリーズドライ保存した多血小板血漿は骨再生に有用である | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-02-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第913号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(歯学) (2017-02-01) | |||||
