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Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides
http://hdl.handle.net/10069/35273
http://hdl.handle.net/10069/35273aceb9b45-b437-4b2e-b83e-0037df23d84d
名前 / ファイル | ライセンス | アクション |
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CPBul63_218.pdf (1.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-05-08 | |||||
タイトル | ||||||
タイトル | Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Demizu, Yosuke
× Demizu, Yosuke× Yamashita, Hiroko× Misawa, Takashi× Doi, Mitsunobu× Tanaka, Masakazu× Kurihara, Masaaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The influence of D -Leu residues on the helical structures of L -Leu-based-nonapeptides was investigated. Specifically, the preferred conformations of four diastereomeric nonapeptides, Boc-(L -Leu- L -Leu-Aib) 3 - OMe (1); Boc-(L -Leu- L -Leu-Aib)2 - L -Leu- D -Leu-Aib-OMe (2), which contained one D -Leu residue; Boc- L -Leu-D -Leu-Aib- L -Leu- L -Leu-Aib- L -Leu- D -Leu-Aib-OMe (3), which contained two D -Leu residues; and Boc-(L -Leu- D -Leu-Aib)3 - OMe (4), were analyzed in solution and in the crystalline state. Peptide 1 formed a righthanded (P) 310 -helix in solution. Peptides 2 and 3 both formed (P ) 310- helices in solution and (P ) α - helices in the crystalline state. Peptide 4 formed a (P ) α -helix both in solution and in the crystalline state. c 2015 The Pharmaceutical Society of Japan α -aminoisobutyric acid; peptide; conformation; helical structure. | |||||
書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 63, 号 3, p. 218-224, 発行日 2015-03-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00092363 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475223 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.c14-00760 | |||||
権利 | ||||||
権利情報 | c 2015 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemical and Pharmaceutical Bulletin, 63(3), pp.218-224; 2015 |