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Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2
http://hdl.handle.net/10069/35720
http://hdl.handle.net/10069/357206b72290d-5833-4bc0-9869-868d44b70c9c
名前 / ファイル | ライセンス | アクション |
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NaCom6_7679.pdf (2.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-08-03 | |||||
タイトル | ||||||
タイトル | Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Zhou, Yue
× Zhou, Yue× Yamada, Naoki× Tanaka, Tomohiro× Hori, Takashi× Yokoyama, Satoru× Hayakawa, Yoshihiro× Yano, Seiji× Fukuoka, Junya× Koizumi, Keiichi× Saiki, Ikuo× Sakurai, Hiroaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylation of EphA2 at Ser-897 is induced by Akt. We show that inflammatory cytokines promote RSK-, not Akt-, dependent phosphorylation of EphA2 at Ser-897. In addition, the RSK-EphA2 signalling pathway controls cell migration and invasion of metastatic breast cancer cells. Moreover, Ser-897-phosphorylated EphA2 co-localizes with phosphorylated active form of RSK in various human tumour specimens, and this double positivity is related to poor survival in lung cancer patients, especially those with a smoking history. Taken together, these results indicate that the phosphorylation of EphA2 at Ser-897 is controlled by RSK and the RSK-EphA2 axis might contribute to cell motility and promote tumour malignant progression. | |||||
書誌情報 |
Nature Communications 巻 6, p. 7679, 発行日 2015-07-09 |
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出版者 | ||||||
出版者 | Nature Publishing Group | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20411723 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/ncomms8679 | |||||
権利 | ||||||
権利情報 | c 2015 Macmillan Publishers Limited. | |||||
権利 | ||||||
権利情報 | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nature Communications, 6, 7679; 2015 |