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Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations
http://hdl.handle.net/10069/36172
http://hdl.handle.net/10069/36172d3b7a7ce-b9b0-4534-b897-1d98616bd3bb
名前 / ファイル | ライセンス | アクション |
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ActMed60_77.pdf (2.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-10 | |||||
タイトル | ||||||
タイトル | Recruitment of distinct immune cell populations to the lung after intratracheal TLR4 signaling activation by two different stimulations | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lung | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TLR4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neutrophils | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dendritic cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Inamura, Yukio
× Inamura, Yukio× Honma, Kiri× Kimura, Daisuke× Miyakoda, Mana× Kimura, Kazumi× Fukudome, Kenji× Nanashima, Atsushi× Nagayasu, Takeshi× Yui, Katsuyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The toll-like receptor 4 (TLR4)-mediated immune response is considered as one of the triggers of acute respiratory distress syndrome. The agonistic monoclonal antibody UT12 specific for the TLR4/MD2 complex induces immune activation in a manner distinct from lipopolysaccharide (LPS). In order to compare the effects of this differential TLR4 signaling activation, we examined immune cell recruitment to the lung following intratracheal inoculation with UT12 and LPS in mice. The increase in pulmonary neutrophils was much higher after LPS treatment compared with UT12 treatment, while CD11bhiCD11+cells increased to similar levels following both treatments. These changes were MyD88-dependent and TRIF-independent. These differential effects on immune cell recruitment to the lung suggest distinct underlying mechanisms in response to TLR4 stimulation. These findings further indicate that TLR signaling can lead to different outcomes depending on the ligand and activation pathway, which may relate to the complex pathogenesis of inflammatory lung diseases. |
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書誌情報 |
Acta medica Nagasakiensia 巻 60, 号 2, p. 77-84, 発行日 2016-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Nagasaki University School of Medicine | |||||
出版者別言語 | ||||||
値 | 長崎大学医学部 | |||||
sortkey | ||||||
値 | 7 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia, 60(2), pp.77-84; 2016 |