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Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet
http://hdl.handle.net/10069/34707
http://hdl.handle.net/10069/34707423d10d9-4004-43ed-9ac5-058cdefba513
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBRC446_212.pdf (925.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-09-29 | |||||
| タイトル | ||||||
| タイトル | Defective adipose tissue development associated with hepatomegaly in cathepsin E-deficient mice fed a high-fat diet | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Adipose tissue | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cathepsin E | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | High-fat diet | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kadowaki, Tomoko
× Kadowaki, Tomoko× Kido, Mizuho A.× Hatakeyama, Junko× Okamoto, Kuniaki× Tsukuba, Takayuki× Yamamoto, Kenji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cathepsin E is an intracellular aspartic proteinase, which is predominantly distributed in immune-related and epithelial cells. However, the role of the enzyme in adipose tissues remains unknown. In this study, we investigated the characteristics of cathepsin E-deficient (CatE-/-) mice fed a high-fat diet (HFD), as a mouse model of obesity. HFD-fed CatE-/- mice displayed reduced body weight gain and defective development of white adipose tissue (WAT) and brown adipose tissue (BAT), compared with HFD-fed wild-type mice. Moreover, fat-induced CatE-/- mice showed abnormal lipid accumulation in non-adipose tissues characterized by hepatomegaly, which is probably due to defective adipose tissue development. Detailed pathological and biochemical analyses showed that hepatomegaly was accompanied by hepatic steatosis and hypercholesterolemia in HFD-induced CatE-/- mice. In fat-induced CatE-/- mice, the number of macrophages infiltrating into WAT was significantly lower than in fat-induced wild-type mice. Thus, the impaired adipose tissue development in HFD-induced CatE-/- mice was probably due to reduced infiltration of macrophages and may lead to hepatomegaly accompanied by hepatic steatosis and hypercholesterolemia. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 446, 号 1, p. 212-217, 発行日 2014-03-28 |
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| 出版者 | ||||||
| 出版者 | Academic Press Inc. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006291X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbrc.2014.02.089 | |||||
| 権利 | ||||||
| 権利情報 | c 2014 Elsevier Inc. All rights reserved. | |||||
| 権利 | ||||||
| 権利情報 | NOTICE: this is the author’s version of a work that was accepted for publication in Biochemical and Biophysical Research Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochemical and Biophysical Research Communications, 446, 1, (2014) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Biochemical and Biophysical Research Communications, 446(1), pp.212-217; 2014 | |||||
