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Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats
http://hdl.handle.net/10069/35028
http://hdl.handle.net/10069/35028dd062742-c807-4428-b79c-2649565920bc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JTS40_43.pdf (662.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-01-23 | |||||
| タイトル | ||||||
| タイトル | Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Behavior | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Central nervous system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Endocrine disruptors | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Learning and memory | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nonylphenol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kawaguchi, Shinichiro
× Kawaguchi, Shinichiro× Kuwahara, Rika× Kohara, Yumi× Uchida, Yutaro× Oku, Yushi× Yamashita, Kimihiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nonylphenol ethoxylate (NPE) is a non-ionic surfactant, that is degraded to short-chain NPE and 4-nonylphenol (NP) by bacteria in the environment. NP, one of the most common environmental endocrine disruptors, exhibits weak estrogen-like activity. In this study, we investigated whether oral administration of NP (at 0.5 and 5 mg/kg doses) affects spatial learning and memory, general activity, emotionality, and fear-motivated learning and memory in male and female Sprague-Dawley (SD) rats. SD rats of both sexes were evaluated using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) that was used to assess spatial learning and memory. In the MAZE test, the time required to reach the reward in male rats treated with 0.5 mg/kg NP group and female rats administered 5 mg/kg NP was significantly longer than that for control animals of the corresponding sex. In other behavioral tests, no significant differences were observed between the control group and either of the NP-treated groups of male rats. In female rats, inner and ambulation values for animals administered 0.5 mg/kg NP were significantly higher than those measured in control animals in open-field test, while the latency in the group treated with 5 mg/kg NP was significantly shorter compared to the control group in step-through passive avoidance test. This study indicates that oral administration of a low-dose of NP slightly impairs spatial learning and memory performance in male and female rats, and alters emotionality and fear-motivated learning and memory in female rats only | |||||
| 書誌情報 |
The Journal of Toxicological Sciences 巻 40, 号 1, p. 43-53, 発行日 2015 |
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| 出版者 | ||||||
| 出版者 | 日本毒性学会 | |||||
| 出版者別言語 | ||||||
| 値 | Japanese Society of Toxicology | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03881350 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18803989 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2131/jts.40.43 | |||||
| 権利 | ||||||
| 権利情報 | c 2015 The Japanese Society of Toxicology | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Journal of Toxicological Sciences, 40(1), pp.43-53; 2015 | |||||
