WEKO3
アイテム
{"_buckets": {"deposit": "a8756aa0-48de-4b42-ae04-317e15fb7ac8"}, "_deposit": {"created_by": 2, "id": "6874", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "6874"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00006874", "sets": ["9"]}, "author_link": ["28801", "28804", "28803", "28800", "28802", "28806", "28808", "28809", "28805", "28807"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "1276", "bibliographicPageStart": "1272", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "European Journal of Neurology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto\u0027s thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves\u0027 disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "European Journal of Neurology, 20(9), pp.1272-1276; 2013", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Blackwell Publishing"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/ene.12169", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2013 EFNS."}, {"subitem_rights": "The definitive version is available at wileyonlinelibrary.com."}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13515101", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakata, Ruka"}], "nameIdentifiers": [{"nameIdentifier": "28800", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Motomura, Masakatsu"}], "nameIdentifiers": [{"nameIdentifier": "28801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masuda, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "28802", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shiraishi, Hirokazu"}], "nameIdentifiers": [{"nameIdentifier": "28803", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tokuda, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "28804", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Taku"}], "nameIdentifiers": [{"nameIdentifier": "28805", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ando, Takao"}], "nameIdentifiers": [{"nameIdentifier": "28806", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshimura, Toshiro"}], "nameIdentifiers": [{"nameIdentifier": "28807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujihata, Mitsuhiro"}], "nameIdentifiers": [{"nameIdentifier": "28808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "28809", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "EJN20_1272.pdf", "filesize": [{"value": "183.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 183100.0, "url": {"label": "EJN20_1272.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/6874/files/EJN20_1272.pdf"}, "version_id": "ae69cd54-0e70-4be1-9135-51429bb89b36"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Associated autoimmune disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Muscle-specific receptor tyrosine kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Myasthenia gravis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Thymus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Titin antibodies", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis"}]}, "item_type_id": "2", "owner": "2", "path": ["9"], "permalink_uri": "http://hdl.handle.net/10069/33896", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-04-01"}, "publish_date": "2014-04-01", "publish_status": "0", "recid": "6874", "relation": {}, "relation_version_is_last": true, "title": ["Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis"], "weko_shared_id": -1}
Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis
http://hdl.handle.net/10069/33896
http://hdl.handle.net/10069/3389682c63fbd-9a40-4671-b3e0-0a5e050e2ddb
名前 / ファイル | ライセンス | アクション |
---|---|---|
EJN20_1272.pdf (183.1 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-04-01 | |||||
タイトル | ||||||
タイトル | Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Associated autoimmune disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Muscle-specific receptor tyrosine kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myasthenia gravis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Thymus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Titin antibodies | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nakata, Ruka
× Nakata, Ruka× Motomura, Masakatsu× Masuda, Tomoko× Shiraishi, Hirokazu× Tokuda, Masahiro× Fukuda, Taku× Ando, Takao× Yoshimura, Toshiro× Tsujihata, Mitsuhiro× Kawakami, Atsushi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG. | |||||
書誌情報 |
European Journal of Neurology 巻 20, 号 9, p. 1272-1276, 発行日 2013-09 |
|||||
出版者 | ||||||
出版者 | Blackwell Publishing | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13515101 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/ene.12169 | |||||
権利 | ||||||
権利情報 | © 2013 EFNS. | |||||
権利 | ||||||
権利情報 | The definitive version is available at wileyonlinelibrary.com. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Neurology, 20(9), pp.1272-1276; 2013 |