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Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis
http://hdl.handle.net/10069/33896
http://hdl.handle.net/10069/3389682c63fbd-9a40-4671-b3e0-0a5e050e2ddb
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
EJN20_1272.pdf (183.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-04-01 | |||||
| タイトル | ||||||
| タイトル | Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Associated autoimmune disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Muscle-specific receptor tyrosine kinase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Myasthenia gravis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Thymus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Titin antibodies | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Nakata, Ruka
× Nakata, Ruka× Motomura, Masakatsu× Masuda, Tomoko× Shiraishi, Hirokazu× Tokuda, Masahiro× Fukuda, Taku× Ando, Takao× Yoshimura, Toshiro× Tsujihata, Mitsuhiro× Kawakami, Atsushi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and purpose: The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients are not clearly defined. Methods: The types of thymus histology, coexisting autoimmune diseases and associated Abs in 83 MuSK-Ab-positive patients nationwide were investigated and were compared with those in AChR-Ab-positive patients followed at our institute (n = 83). As for the autoantibodies associated with thymoma, titin Abs were measured. Results: Thymoma was not present in any of the MuSK-Ab-positive patients but presented in 21 patients (25.3%) amongst the AChR-Ab-positive patients. Titin Abs were absent in MuSK-Ab-positive patients but positive in 25 (30.1%) of the AChR-Ab-positive patients. Concomitant autoimmune diseases were present in eight MuSK-Ab-positive patients (9.6%) amongst whom Hashimoto's thyroiditis and rheumatoid arthritis predominated, whereas 22 AChR-Ab-positive patients (26.5%) had one or more concomitant autoimmune diseases of which Graves' disease predominated. Conclusions: Differences in frequency of thymoma and thymic hyperplasia, coexisting autoimmune diseases and autoantibody positivity between MuSK-Ab-positive and AChR-Ab-positive MG were indicated, suggesting that, in contrast with AChR-Ab-positive MG, thymus does not seem to be involved in the pathogenic mechanisms of MuSK-Ab-positive MG. | |||||
| 書誌情報 |
European Journal of Neurology 巻 20, 号 9, p. 1272-1276, 発行日 2013-09 |
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| 出版者 | ||||||
| 出版者 | Blackwell Publishing | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13515101 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/ene.12169 | |||||
| 権利 | ||||||
| 権利情報 | © 2013 EFNS. | |||||
| 権利 | ||||||
| 権利情報 | The definitive version is available at wileyonlinelibrary.com. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | European Journal of Neurology, 20(9), pp.1272-1276; 2013 | |||||
