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CD8+ T cell activation by murine erythroblasts infected with malaria parasites
http://hdl.handle.net/10069/32141
http://hdl.handle.net/10069/32141ec9e21db-5b0e-4458-9376-ca181acdf8f0
| 名前 / ファイル | ライセンス | アクション |
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SciRep3_1572.pdf (2.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2013-06-05 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | CD8+ T cell activation by murine erythroblasts infected with malaria parasites | |||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
| 著者 |
Imai, Takashi
× Imai, Takashi
× Ishida, Hidekazu
× Suzue, Kazutomo
× Hirai, Makoto
× Taniguchi, Tomoyo
× Okada, Hiroko
× Suzuki, Tomohisa
× Shimokawa, Chikako
× Hisaeda, Hajime
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Recent studies show that some human malaria parasite species Plasmodium falciparum and P. vivax parasitize erythroblasts; however, the biological and clinical significance of this is unclear. To investigate further, we generated a rodent malaria parasite (P. yoelii 17XNL) expressing GFP-ovalbumin (OVA). Its infectivity to erythroblasts was confirmed, and parasitized erythroblasts were capable of initiating malaria infections. Experiments showed that MHC class I molecules were highly expressed on parasitized erythroblasts. As CD8+ T cells recognize MHC class I and peptide complexes on target cells, and are involved in protection or pathology against malaria, we examined whether erythroblasts are targeted by CD8+ T cells. Purified non-parasitized erythroblasts pulsed with OVA peptides were recognized by OVA-specific CD8 + T cells. Crucially, parasitized erythroblasts isolated from GFP-OVA-, but not GFP-infected-mice, activated OT-I CD8+ T cells, indicating that CD8+ T cells recognize parasitized erythroblasts in an antigen-specific manner. | |||||||||||||||||||||||
| 書誌情報 |
Scientific Reports 巻 3, p. 1572, 発行日 2013-03-28 |
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| 出版者 | Nature Publishing Group | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 20452322 | |||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | 10.1038/srep01572 | |||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||
| 権利情報 | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ | |||||||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | Scientific Reports, 3, 1572; 2013 | |||||||||||||||||||||||
