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Evaluation of Surgical Resection for Gallbladder Carcinoma at a Japanese Cancer Institute
http://hdl.handle.net/10069/30981
http://hdl.handle.net/10069/30981e3609406-7fc5-4f65-aa2e-f8353fd782c0
名前 / ファイル | ライセンス | アクション |
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HepGas59_1717.pdf (241.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-01 | |||||
タイトル | ||||||
タイトル | Evaluation of Surgical Resection for Gallbladder Carcinoma at a Japanese Cancer Institute | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Curability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gallbladder carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Survival | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tumor markers | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nanashima, Atsushi
× Nanashima, Atsushi× Tobinaga, Syuuichi× Abo, Takafumi× Morisaki, Tomohito× Uehara, Ryouhei× Takeshita, Hiroaki× Nonaka, Takashi× Hidaka, Shigekazu× Takeshima, Fuminao× Ohnita, Ken× Isomoto, Hajime× Kunizaki, Masaki× Sawai, Terumitsu× Nakao, Kazuhiko× Nagayasu, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aims: Surgical resection is a radical treatment option for gallbladder carcinoma (GBC); however, it is still difficult to cure and patient prognosis is poor. An assessment of the surgical results and chemotherapy options may elucidate effective treatments. Methodology: We retrospectively examined the demographics, surgical records and outcome in 33 patients with GBC undergoing surgical resection. Results: Postoperative cancer recurrence was observed in 36% of patients. Mean cancer-free survival time was 84 months and 3-year cancer-free survival rate was 70% Mean overall survival time was 96 months and 5-year overall survival rate was 52%. The 3-year cancer-free survival and the 5-year overall survival were significantly different between the final tumor stages (p<0.001). Higher CEA and CA19-9 level were significantly related to poor overall survival (p<0.05). Macroscopically, papillary type tumor showed significantly better overall survival compared to nodular or flat types (p<0.05). Degree of invasion, node metastasis, moderate or poor differentiation, vascular or perineural invasion and invasion of the liver or hepatoduodenal ligament were significantly associated with poor overall survival (p<0.05). A cancer-free margin at the hepatic cut end and dissected periductal structures showed a significantly poor prognosis (p<0.05). The overall survival in final curability A was significantly associated with better curability than B or C (p<0.05). Conclusions: Radically extended surgical resection for GBC is necessary to obtain improved patient survival and new adjuvant chemotherapy would be expected to improve results after surgery. | |||||
書誌情報 |
Hepato-gastroenterology 巻 59, 号 118, p. 1717-1721, 発行日 2012-09 |
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出版者 | ||||||
出版者 | H.G.E. Update Medical Publishing Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01726390 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 22819898 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.5754/hge10299 | |||||
権利 | ||||||
権利情報 | © H.G.E. Update Medical Publishing S.A. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Hepato-gastroenterology, 59(118), pp.1717-1721; 2012 |