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Diastereoselective addition to N-acyliminium ions with aryl- and alkenyl boronic acids via a Petasis-type reaction
http://hdl.handle.net/10069/29073
http://hdl.handle.net/10069/29073c8ec6831-34b8-4180-92b0-a0245cd09321
名前 / ファイル | ライセンス | アクション |
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RSCAd2_2266.pdf (407.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-15 | |||||
タイトル | ||||||
タイトル | Diastereoselective addition to N-acyliminium ions with aryl- and alkenyl boronic acids via a Petasis-type reaction | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alkenyl | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Boronic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diastereoselective additions | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Diastereoselective synthesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nucleophilic additions | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Piperidine rings | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Receptor antagonists | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stereoselectivity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mizuta, Satoshi
× Mizuta, Satoshi× Onomura, Osamu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A highly diastereoselective synthesis of 2,3-disubstituted piperidines has been accomplished through nucleophilic additions to N-acyliminium ions with aryl- and alkenyl boronic acids. A reversal of stereoselectivity depending on a β-substituent on the piperidine ring was observed in the alkenylation reactions with (E)-styrylboronic acid. Our strategy was applied in the key step for the synthesis of the neurokinin NK1 receptor antagonist (±)-L-733, 060. | |||||
書誌情報 |
RSC Advances 巻 2, 号 6, p. 2266-2269, 発行日 2012-03-14 |
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出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20462069 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1039/c2ra01254e | |||||
権利 | ||||||
権利情報 | © 2012 The Royal Society of Chemistry. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | RSC Advances, 2(6), pp.2266-2269; 2012 |