WEKO3
アイテム
Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients.
http://hdl.handle.net/10069/26411
http://hdl.handle.net/10069/26411854a3a69-2180-4760-8974-18ea525fbcff
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Talanta85_230.pdf (351.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-11-16 | |||||
| タイトル | ||||||
| タイトル | Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Luminol chemiluminescence | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Photo-induced | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Reactive oxygen species | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rheumatoid arthritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Vitamin K homologues | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ahmed, Sameh
× Ahmed, Sameh× Kishikawa, Naoya× Ohyama, Kaname× Imazato, Takahiro× Ueki, Yukitaka× Kuroda, Naotaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Vitamin K is a fat-soluble vitamin involved in blood coagulation and bone metabolism. The detection and monitoring of vitamin K homologues in rheumatoid arthritis (RA) patients is a challenging problem due to the smaller concentrations of vitamin K and the presence of several interfering medications. Therefore, this study aimed to develop a new highly sensitive and selective chemiluminescence (CL) method designated to quantify vitamin K homologues in plasma of RA patients including phylloquinone (PK, vitamin K(1)), menaquinone-4 (MK-4, vitamin K(2)) and menaquinone-7 (MK-7, vitamin K(2)). The method was based on the unique photochemical properties of vitamin K homologues that were exploited for selective luminol CL reaction. The correlation coefficients of 0.998 or more were obtained in the concentration ranges of 0.1-100 ng mL(-1) vitamin K homologues. The detection limits were 0.03-0.1 ng mL(-1) in human plasma for vitamin K homologues. The developed HPLC-CL system was successfully applied for selective determination of vitamin K homologues in plasma of RA patients. The developed method may provide a useful tool for monitoring vitamin K homologues in different clinical studies such as RA, osteoporosis and hepatocellular carcinoma in which vitamin K is intervented. | |||||
| 書誌情報 |
Talanta 巻 85, 号 1, p. 230-236, 発行日 2011-07-15 |
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| 出版者 | ||||||
| 出版者 | Elsevier BV | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00399140 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18733573 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00856594 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 21645693 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.talanta.2011.03.059 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2011 Elsevier B.V. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Talanta, 85(1), pp.230-236; 2011 | |||||
