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A parenteral DNA vaccine protects against pneumonic plague.
http://hdl.handle.net/10069/23688
http://hdl.handle.net/10069/236883239bb62-5b7e-41b7-88d0-14128c26a4a8
名前 / ファイル | ライセンス | アクション |
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Vaccine28_3219.pdf (810.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-30 | |||||
タイトル | ||||||
タイトル | A parenteral DNA vaccine protects against pneumonic plague. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphotactin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mucosal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pneumonic plague | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vaccines | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamanaka, Hitoki
× Yamanaka, Hitoki× Hoyt, Teri× Yang, Xinghong× Bowen, Richard× Golden, Sarah× Crist, Kathryn× Becker, Todd× Maddaloni, Massimo× Pascual, David W |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The chemokine, lymphotactin (LTN), was tested as a molecular adjuvant using bicistronic DNA vaccines encoding the protective Yersinia capsular (F1) antigen and virulence antigen (V-Ag) as a F1-V fusion protein. The LTN-encoding F1-V or V-Ag vaccines were given by the intranasal (i.n.) or intramuscular (i.m.) routes, and although serum IgG and mucosal IgA antibodies (Abs) were induced, F1-Ag boosts were required for robust anti-F1-Ag Abs. Optimal efficacy against pneumonic plague was obtained in mice i.m.-, not i.n.-immunized with these DNA vaccines. These vaccines stimulated elevated Ag-specific Ab-forming cells and mixed Th cell responses, with Th17 cells markedly enhanced by i.m. immunization. These results show that LTN can be used as a molecular adjuvant to enhance protective immunity against plague. | |||||
書誌情報 |
Vaccine 巻 28, 号 18, p. 3219-3230, 発行日 2010-04-19 |
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出版者 | ||||||
出版者 | Elsevier Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0264410X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13588745 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10491877 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20197132 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.vaccine.2010.02.022 | |||||
権利 | ||||||
権利情報 | Copyright © 2010 Elsevier Ltd All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Vaccine, 28(18), pp.3219-3230; 2010 |