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Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.
http://hdl.handle.net/10069/22308
http://hdl.handle.net/10069/223080dc63d71-2d01-4980-ae47-4bbc4bad60b2
名前 / ファイル | ライセンス | アクション |
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JouBio145_565.pdf (327.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-11-02 | |||||
タイトル | ||||||
タイトル | Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aspartic proteinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cathepsin E | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell adhesion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chemotaxis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Knockout | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Macrophages | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tsukuba, Takayuki
× Tsukuba, Takayuki× Yanagawa, Michiyo× Okamoto, Kuniaki× Okamoto, Yoshiko× Yasuda, Yoshiyuki× Nakayama, Keiichi I× Kadowaki, Tomoko× Yamamoto, Kenji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cathepsin E is an endo-lysosomal aspartic proteinase exclusively present in immune system cells. Previous studies have shown that cathepsin E-deficient (CatE(-/-)) mice display aberrant immune responses such as atopic dermatitis and higher susceptibility to bacterial infection. However, the mechanisms underlying abnormal immune responses induced by cathepsin E deficiency are still unclear. In this study, we found that the cell-surface levels of chemotactic receptors, including chemokine receptor (CCR)-2 and N-formyl peptide receptors (FPRs), were clearly diminished in CatE(-/-)macrophages compared with those in wild-type cells. Consistently, chemotaxis of CatE(-/-)macrophages to MCP-1 and N-formyl-methionyl-leucyl-phenylalanine was also decreased. Similar to the chemotactic receptors, the surface expressions of the adhesion receptors CD18 (integrin beta(2)) and CD 29 (integrin beta(1)) in CatE(-/-) macrophages were significantly decreased, thereby reducing cell attachment of CatE(-/-) macrophages. These results indicate that the defects in chemotaxis and cell adhesion are likely to be involved in the imperfect function of CatE(-/-)macrophages. | |||||
書誌情報 |
Journal of biochemistry 巻 145, 号 5, p. 565-573, 発行日 2009-05 |
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出版者 | ||||||
出版者 | The Japanese Biochemical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021924X | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1756-2651 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00694073 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 19174547 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/jb/mvp016 | |||||
権利 | ||||||
権利情報 | c The Authors 2009. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of biochemistry, 145(5), pp.565-573; 2009 |