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Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.
http://hdl.handle.net/10069/22594
http://hdl.handle.net/10069/22594432b3118-2cca-4ef7-b0f0-956ebb271829
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CDT22_293.pdf (441.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-12-07 | |||||
| タイトル | ||||||
| タイトル | Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fasudil | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ischemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Reperfusion | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rho-kinase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Stunned myocardium | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Swine | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Shibata, Itsuko
× Shibata, Itsuko× Yoshitomi, Osamu× Use, Tadasuke× Ureshino, Hiroyuki× Cho, Sungsam× Maekawa, Takuji× Hara, Tetsuya× Sumikawa, Koji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVES: We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. MATERIALS AND METHODS: All swine were subjected to 12 min ischemia followed by reperfusion to generate stunned myocardium. Group A (n = 11) received saline in place of fasudil both before ischemia and after reperfusion. Group B (n = 10) received 30 min intravenous fasudil at a rate of 13 mug/kg/min starting 45 min before ischemia and received saline after reperfusion. Groups C (n = 10) and D (n = 9) received saline before ischemia, and received fasudil at a rate of 13 microg kg(-1) min(-1) starting just before reperfusion in group C and 30 min after reperfusion in group D. In both groups, treatment lasted 30 min. Myocardial contractility was assessed by percent segment shortening (%SS). RESULTS AND DISCUSSION: Three swine in group A, 2 swine in each of groups B and C, and one swine in group D had ventricular fibrillation or tachycardia after reperfusion and were excluded from further analysis. The changes of %SS from baseline at 90 min after reperfusion in groups B and C were 68 +/- 8% and 75 +/- 8%, respectively, which were significantly higher than in group A or D (47 +/- 10% or 43 +/- 8%). CONCLUSION: We conclude that fasudil administered before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium. | |||||
| 書誌情報 |
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 巻 22, 号 4, p. 293-298, 発行日 2008-08 |
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| 出版者 | ||||||
| 出版者 | Springer Netherlands | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09203206 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1573-7241 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10691796 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 18470606 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s10557-008-6106-y | |||||
| 権利 | ||||||
| 権利情報 | c Springer Science+Business Media, LLC 2008 | |||||
| 権利 | ||||||
| 権利情報 | The original publication is available at www.springerlink.com | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Cardiovascular Drugs and Therapy, 22(4), pp.293-298; 2008 | |||||
