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{"subitem_subject": "Reperfusion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rho-kinase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Stunned myocardium", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Swine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in 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Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine.
http://hdl.handle.net/10069/22594
http://hdl.handle.net/10069/22594432b3118-2cca-4ef7-b0f0-956ebb271829
名前 / ファイル | ライセンス | アクション |
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CDT22_293.pdf (441.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-12-07 | |||||
タイトル | ||||||
タイトル | Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Fasudil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ischemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reperfusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rho-kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stunned myocardium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Swine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shibata, Itsuko
× Shibata, Itsuko× Yoshitomi, Osamu× Use, Tadasuke× Ureshino, Hiroyuki× Cho, Sungsam× Maekawa, Takuji× Hara, Tetsuya× Sumikawa, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVES: We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine. MATERIALS AND METHODS: All swine were subjected to 12 min ischemia followed by reperfusion to generate stunned myocardium. Group A (n = 11) received saline in place of fasudil both before ischemia and after reperfusion. Group B (n = 10) received 30 min intravenous fasudil at a rate of 13 mug/kg/min starting 45 min before ischemia and received saline after reperfusion. Groups C (n = 10) and D (n = 9) received saline before ischemia, and received fasudil at a rate of 13 microg kg(-1) min(-1) starting just before reperfusion in group C and 30 min after reperfusion in group D. In both groups, treatment lasted 30 min. Myocardial contractility was assessed by percent segment shortening (%SS). RESULTS AND DISCUSSION: Three swine in group A, 2 swine in each of groups B and C, and one swine in group D had ventricular fibrillation or tachycardia after reperfusion and were excluded from further analysis. The changes of %SS from baseline at 90 min after reperfusion in groups B and C were 68 +/- 8% and 75 +/- 8%, respectively, which were significantly higher than in group A or D (47 +/- 10% or 43 +/- 8%). CONCLUSION: We conclude that fasudil administered before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium. | |||||
書誌情報 |
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 巻 22, 号 4, p. 293-298, 発行日 2008-08 |
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出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09203206 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1573-7241 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10691796 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18470606 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10557-008-6106-y | |||||
権利 | ||||||
権利情報 | c Springer Science+Business Media, LLC 2008 | |||||
権利 | ||||||
権利情報 | The original publication is available at www.springerlink.com | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cardiovascular Drugs and Therapy, 22(4), pp.293-298; 2008 |