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CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea
http://hdl.handle.net/10069/21527
http://hdl.handle.net/10069/2152783189f9f-c73f-4800-bace-a5b764b2f656
名前 / ファイル | ライセンス | アクション |
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TMH36_93.pdf (64.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-09 | |||||
タイトル | ||||||
タイトル | CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CTLA-4 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | IgE | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malaria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Osawa, Hikota
× Osawa, Hikota× Troye-Blomberg, Marita× Hirayama, Kenji× Kikuchi, Mihoko× Hombhanje, Francis× Tanihata, Takeo× Udomsangpetch, Rachanee× Björkman, Anders× Kobayakawa, Takatoshi× Kaneko, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In malaria endemic areas, people naturally acquire an age-related immunity to malaria. Part of this immunity involves anti-malarial specific antibodies. Acquisition of these malaria-specific antibodies depends not only on exposure to malaria parasites but also on the human genetic predisposition. CTLA-4 is a costimulatory molecule that delivers an inhibitory signal to suppress T-cell as well as B-cell responses. We investigated associations between malaria-specific antibody levels and CTLA-4 polymorphisms in 189 subjects living in a hyper-endemic area of Papua New Guinea (PNG), where both P. falciparum and P. vivax are prevalent. We determined P. falciparum/ P. vivax specific IgG/IgE levels (Pf-IgG, Pv-IgG, Pf-IgE, Pv-IgE) and polymorphisms in the CTLA-4 gene at position -1661 promoter region (A/G), the +49 exon 1 non-synonymous mutation (A/G), and the +6230 3‘-UTR (A/G). All quantified antibody levels were significantly higher in subjects > 5 years (n = 150) than in subjects 5 years of age (n = 39). In children 5 years old, significant associations were detected between CTLA-4 +49 (GG/AG vs. AA) and Pv-IgG (median 18.7 vs. 13.7 Μg/ml, P = 0.017) and Pv-IgE (266.6 vs. 146.5 pg/ml, P = 0.046). No significant difference was observed in subjects > 5 years old. These results suggest that the CTLA-4+49 polymorphism influenced Pv-IgG and Pv-IgE levels among children less than five years old in the studied population, which may regulate the age- and species-specific clinical outcomes of malaria infection. | |||||
書誌情報 |
Tropical medicine and health 巻 36, 号 2, p. 93-100, 発行日 2008-06 |
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出版者 | ||||||
出版者 | 日本熱帯医学会 | |||||
出版者 | ||||||
出版者 | The Japanese Society of Tropical Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488945 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11912860 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2149/tmh.2008-07 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2008 日本熱帯医学会 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health Vol. 36 No. 2, 2008, pp. 93-100 |