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The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats
http://hdl.handle.net/10069/19110
http://hdl.handle.net/10069/19110b7093c94-497b-4256-9612-04bec983cea8
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
RR44_2_111_115.pdf (945.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-08-12 | |||||
| タイトル | ||||||
| タイトル | The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Kefir | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Radiation-induced apoptosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | X-ray | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rats | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Colon | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsuu, Mutsumi
× Matsuu, Mutsumi× Shichijo, Kazuko× Okaichi, Kumio× Wen, Chun Yang× Fukuda, Eiichiro× Nakashima, Masahiro× Nakayama, Toshiyuki× Shirahata, Sanetaka× Tokumaru, Sennosuke× Sekine, Ichiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate the effect of fermented milk kefir on X-ray-induced apoptosis in the colon of rats, we examined the apoptotic index, the mean number of apoptotic cells detected by H&E staining per crypt in the colon, in control rats and kefir-pretreated rats drinking kefir for 12 days before irradiation. Apoptotic cells were confirmed by TUNEL staining, and active caspase-3 expression was studied by immunohistochemistry. The cell position of apoptotic cells and active caspase-3 positive cells were examined. The apoptotic index of kefirtreated rats was significantly (p < 0.05) decreased 2 h after 1 Gy irradiation in comparison with control rats at crypt cell positions 1-3, 5-7, 13, and 15. Active caspase-3 expression in the kefir-treated rats was also significantly (p < 0.05) reduced in comparison with control rats 2 h after 1 Gy irradiation at crypt cell positions 1-4, 13, and 15. This study indicated that kefir protects colonic crypt cells against radiation-induced apoptosis, which was most pronounced in the stem cell region of the crypt. The antiapoptotic effect of fermented milk kefir was due to the inhibition of caspase-3 activation. | |||||
| 書誌情報 |
Journal of radiation research 巻 44, 号 2, p. 111-115, 発行日 2003-06 |
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| 出版者 | ||||||
| 出版者 | 日本放射線影響学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 04493060 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00705792 | |||||
| 権利 | ||||||
| 権利情報 | 日本放射線影響学会 | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of radiation research. 2003, 44(2), p.111-115 | |||||
