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Enantioselective Synthesis of 2,4,5-Trisubstituted Tetrahydropyrans via Peptide-Catalyzed Michael Addition Followed by Kishi’s Reductive Cyclization
http://hdl.handle.net/10069/39289
http://hdl.handle.net/10069/392890b541c3a-d7aa-43bd-aaae-5edfa6e682c4
| 名前 / ファイル | ライセンス | アクション |
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2019_Het_99_989.pdf (355.1 kB)
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2019_Het_99_989si.pdf (605 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-07-03 | |||||
| タイトル | ||||||
| タイトル | Enantioselective Synthesis of 2,4,5-Trisubstituted Tetrahydropyrans via Peptide-Catalyzed Michael Addition Followed by Kishi’s Reductive Cyclization | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ueda, Atsushi
× Ueda, Atsushi× Higuchi, Mei× Umeno, Tomohiro× Tanaka, Masakazu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An enantioselective synthesis of 2,4,5-trisubstituted tetrahydropyrans has been achieved in four steps from α,β-unsaturated ketones and dimethyl malonate by peptide-catalyzed asymmetric Michael addition and diastereoselective construction of tetrahydropyran rings by Kishi’s reductive cyclization as key steps. A variety of α,β-unsaturated ketones were converted to the 1,4-products with high enantioselectivities (83－98% ee). | |||||
| 書誌情報 |
HETEROCYCLES 巻 99, 号 2, p. 989-1002, 発行日 2018-11-22 |
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| 出版者 | ||||||
| 出版者 | 日本複素環化学研究所 | |||||
| 出版者別言語 | ||||||
| 値 | Japan Institute of Heterocyclic Chemistry | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03855414 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3987/COM-18-S(F)63 | |||||
| 権利 | ||||||
| 権利情報 | © 2018 The Japan Institute of Heterocyclic Chemistry | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | HETEROCYCLES, 99(2), pp.989-1002; 2019 | |||||
