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Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B
http://hdl.handle.net/10069/15916
http://hdl.handle.net/10069/159165715d81f-2591-41db-9702-471a32230722
名前 / ファイル | ライセンス | アクション |
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acta38_02_13_t.pdf (12.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||
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公開日 | 2008-03-13 | |||||||
タイトル | ||||||||
タイトル | Association of the Hepatic Expression of β2-Microglobulin with Spontaneous Hepatitis Be Antigen Seroconversion in Chronic Hepatitis B | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | croglobulin | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | HBcAg | |||||||
キーワード | ||||||||
主題Scheme | Other | |||||||
主題 | chronic hepatitisB | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | departmental bulletin paper | |||||||
著者 |
Kinoshita, Noboru
× Kinoshita, Noboru
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Hepatic expression of hepatitis B core antigen(HBcAg)and β2- mi croglobulin (β2-MG) was studied in 42 patients with liver biopsy-proven chronic hepatitis B; 31 were hepatitis Be antigen (HBeAg)-seropositive and 11 were anti-HBeAg antibody (anti- HBe)-seropositive at base line. The degrees of expression of both HBcAg and β2-MG at base line were significantly higher in HBeAgseropositive patients than in anti-HBe-seropositive patients (p < 0.001 and p < 0.001, respectively). During two-year-follow-up, 14 of 31 HBeAg-seropositive patients were seroconverted to anti-HBe (HBe-seroconversion). When the base line hepatic expression of HBcAg and β2-MG was compared between the patients with subsequent HBe-seroconversion and the non-soroconverted patients, β2-MG expression on hepatocytes in the patients with subsequent HBe-seroconversion was significantly more intense than that in the non-soroconverted patients (p < 0.025). In contrast, the degrees of HBcAg expression at base line were not different between the two groups. These results suggest that the hepatic expression of β2-MG as well as that of HBcAg correlates with the serum level of HBeAg and that the increased expression of β2-MG is followed by HBe-seroconversion in patients with chronic hepatitis B. | |||||||
書誌情報 |
Acta medica Nagasakiensia 巻 38, 号 2-4, p. 95-99, 発行日 1993-12-25 |
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ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 00016055 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA00508430 | |||||||
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出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
sortkey | ||||||||
P00095-P00099 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Acta medica Nagasakiensia. 1993, 38(2-4), p.95-99 |