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Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes
http://hdl.handle.net/10069/8370
http://hdl.handle.net/10069/8370feaeb10a-8bdc-46dd-94ef-b88dc71d644a
名前 / ファイル | ライセンス | アクション |
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JHS51_93.pdf (150.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bisphenol A metabolite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogenic activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vitellogenin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | medaka | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nagae, Masaki
× Nagae, Masaki× Shiroyama, Ken'Ichirou× Inoue, Mihoka× Hara, Akihiko× Takao, Yuji× Kohra, Shinya× Ishibashi, Yasuhiro× Tominaga, Nobuaki× Yoshihara, Shin'Ichi× Arizono, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the estrogenic activity of a bisphenol A (BPA) metabolite (4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene; MBP) in male medaka (Oryzias latipes) using vitellogenin (Vg, Vg1 and Vg2) as a biomarker. Male d-rR medaka were exposed to various concentrations of estradiol-17β (E2), MBP and BPA for 3 days, and then the serum Vg concentration was measured using specific chemiluminescent immunoassays. The estimated relative estrogenic activities of MBP and BPA compared with E2 (100%) were 1.3-1.4% and 0.00010-0.00023%, respectively. These findings indicated that MBP has about 104-fold higher estrogenic potency than the parent BPA and about 1/50 that of E2 for Vg synthesis in medaka. This is the first study to show that MBP can act as a highly potent estrogen agonist in living organisms. | |||||
書誌情報 |
Journal of Health Science 巻 51, 号 1, p. 93-95, 発行日 2005-02 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13449702 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5207 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11316464 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/jhs.51.93 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/jhs.51.93 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Health Science v.51(1) p.93-95, 2005 |