| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-02-02 |
| タイトル |
|
|
タイトル |
Burden and mortality of sepsis and septic shock at a high-volume, single-center in Vietnam: a retrospective study |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Sepsis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
septic shock |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
mortality |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
positive blood culture |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hieu, Truong Hong
Ngoc Thao, Pham Thi
Cucè, Federica
Nam, Nguyen Hai
Reda, Abdullah
Hassan, Osman Gamal
Hung, Le Thanh
Kim Quyen, Dinh Thi
Abdul Aziz, Jeza M
Le Quang, Loc
Carameros, Alison Marie
Huy, Nguyen Tien
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Sepsis and septic shock have high mortality rates and often require a prolonged hospital stay. Patient outcomes may vary according to multiple factors. We aim to determine the prevalence of antimicrobial resistance and factors associated with mortality and hospital stay.
Methods: Clinical and microbiological data of patients with sepsis or septic shock were retrospectively collected for 15 months. Patients with negative blood cultures and patients that did not meet the SEPSIS 3 criteria were excluded.
Results: We included 48 septic shock and 28 septic patients (mean APACHE II 20.32 ± 5.61 and mean SOFA 9.41 ± 3.17), with a mean age of 60.5 ± 16.8 years and 56.6% males. WBCs, neutrophils, INR, and fibrinogen levels were significantly associated with mortality. 59.5% of the cultured bacteria were gram-negative (most common E. coli) and 27.8% were gram-positive (most common S. aureus), while 7.6% were other types of bacteria and 5.1% were fungi. Resistance patterns to gram-negative were varying, and resistance to piperacillin/tazobactam, carbapenems, and aminoglycosides were from 60% to 100% (A. baumanii), while they were highly sensitive to Colistin. E. coli was also resistant to ceftriaxone (77.8%) and sulbactam/cefoperazone (44.4%). Resistance rates for Gram-positives were high, from 86% to 100% for oxacillin, while for vancomycin, teicoplanin, and linezolid, they were often low but arrived up to 42.8%. According to our logistic regression analysis, patients over 65 year-old and those who received corticosteroids had a significantly increased risk of in-hospital mortality (OR: 4.0; OR: 4.8).
Conclusion: Sepsis still poses a significant threat to patients’ health, even when positive blood culture results allow the administration of specific antibiotic treatment. |
| 書誌情報 |
Hospital Practice
巻 50,
号 5,
p. 407-415,
発行日 2022-11-07
|
| 出版者 |
|
|
出版者 |
Taylor ＆ Francis |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2154-8331 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1080/21548331.2022.2133414 |
| 権利 |
|
|
権利情報 |
This is an Accepted Manuscript of an article published by Taylor & Francis in Hospital Practice on 07 Nov 2022, available online: http://www.tandfonline.com/10.1080/21548331.2022.2133414. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Hospital Practice, 50(5), pp.407-415; 2022 |
HP50_407.pdf (639.2 kB)
