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Burden and mortality of sepsis and septic shock at a high-volume, single-center in Vietnam: a retrospective study
http://hdl.handle.net/10069/00042025
http://hdl.handle.net/10069/000420256ca18c98-2f8b-476c-b46f-a77372dec9cc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HP50_407.pdf (639.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2023-02-02 | |||||
| タイトル | ||||||
| タイトル | Burden and mortality of sepsis and septic shock at a high-volume, single-center in Vietnam: a retrospective study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sepsis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | septic shock | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mortality | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | positive blood culture | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hieu, Truong Hong
× Hieu, Truong Hong× Ngoc Thao, Pham Thi× Cucè, Federica× Nam, Nguyen Hai× Reda, Abdullah× Hassan, Osman Gamal× Hung, Le Thanh× Kim Quyen, Dinh Thi× Abdul Aziz, Jeza M× Le Quang, Loc× Carameros, Alison Marie× Huy, Nguyen Tien |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Sepsis and septic shock have high mortality rates and often require a prolonged hospital stay. Patient outcomes may vary according to multiple factors. We aim to determine the prevalence of antimicrobial resistance and factors associated with mortality and hospital stay. Methods: Clinical and microbiological data of patients with sepsis or septic shock were retrospectively collected for 15 months. Patients with negative blood cultures and patients that did not meet the SEPSIS 3 criteria were excluded. Results: We included 48 septic shock and 28 septic patients (mean APACHE II 20.32 ± 5.61 and mean SOFA 9.41 ± 3.17), with a mean age of 60.5 ± 16.8 years and 56.6% males. WBCs, neutrophils, INR, and fibrinogen levels were significantly associated with mortality. 59.5% of the cultured bacteria were gram-negative (most common E. coli) and 27.8% were gram-positive (most common S. aureus), while 7.6% were other types of bacteria and 5.1% were fungi. Resistance patterns to gram-negative were varying, and resistance to piperacillin/tazobactam, carbapenems, and aminoglycosides were from 60% to 100% (A. baumanii), while they were highly sensitive to Colistin. E. coli was also resistant to ceftriaxone (77.8%) and sulbactam/cefoperazone (44.4%). Resistance rates for Gram-positives were high, from 86% to 100% for oxacillin, while for vancomycin, teicoplanin, and linezolid, they were often low but arrived up to 42.8%. According to our logistic regression analysis, patients over 65 year-old and those who received corticosteroids had a significantly increased risk of in-hospital mortality (OR: 4.0; OR: 4.8). Conclusion: Sepsis still poses a significant threat to patients’ health, even when positive blood culture results allow the administration of specific antibiotic treatment. |
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| 書誌情報 |
Hospital Practice 巻 50, 号 5, p. 407-415, 発行日 2022-11-07 |
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| 出版者 | ||||||
| 出版者 | Taylor ＆ Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2154-8331 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/21548331.2022.2133414 | |||||
| 権利 | ||||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis in Hospital Practice on 07 Nov 2022, available online: http://www.tandfonline.com/10.1080/21548331.2022.2133414. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Hospital Practice, 50(5), pp.407-415; 2022 | |||||
