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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations
http://hdl.handle.net/10069/00042370
http://hdl.handle.net/10069/0004237058dccb84-39c9-4e65-8392-8a87beabc282
名前 / ファイル | ライセンス | アクション |
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AAC67_e012432.pdf (341.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2023-05-01 | |||||
タイトル | ||||||
タイトル | Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Candida auris | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | yeast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antifungal resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gastrointestinal tract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FKS1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | echinocandins | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hirayama, Tatsuro
× Hirayama, Tatsuro× Miyazaki, Taiga× Sumiyoshi, Makoto× Ito, Yuya× Ashizawa, Nobuyuki× Takeda, Kazuaki× Iwanaga, Naoki× Takazono, Takahiro× Yamamoto, Kazuko× Izumikawa, Koichi× Yanagihara, Katsunori× Makimura, Koichi× Tsukamoto, Kazuhiro× Kohno, Shigeru× Mukae, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo; however, the MICs of isolates with mutation in R1354 remained below the micafungin breakpoint in vitro. | |||||
書誌情報 |
Antimicrobial Agents and Chemotherapy 巻 67, 号 4, p. e012432, 発行日 2023-03-15 |
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出版者 | ||||||
出版者 | American Society for Microbiology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0066-4804 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1128/aac.01243-22 | |||||
権利 | ||||||
権利情報 | © 2023 American Society forMicrobiology. Antimicrobial agents and chemotherapy, 67(4), art. no. e0124322; 2023. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Antimicrobial agents and chemotherapy, 67(4), art. no. e0124322; 2023 |