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Clinical presentation of CL varies from a self-healing\ninfection to a chronic form of the disease determined by the virulence of infecting Leishmania\nspecies and host immune responses to the parasite. Mouse models of CL show\ncontradictory roles of lymphocytes in pathogenesis, while acquired immune responses are\nresponsible for host protection from diseases. To reconcile the inconclusive roles of\nacquired immune responses in pathogenesis, we infected mice from various genetic backgrounds\nwith two pathogenic strains of Leishmania major, Friedlin or 5ASKH, and assessed\nthe outcome of the infections. Our findings showed that the genetic backgrounds of L. major\ndetermine the impact of lymphocytes for pathogenesis. 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Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner
http://hdl.handle.net/10069/39604
http://hdl.handle.net/10069/39604fc98d5b9-33eb-485f-bebc-de88cda6ff81
名前 / ファイル | ライセンス | アクション |
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PLoSNeg13_7865.pdf (1.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-12-19 | |||||
タイトル | ||||||
タイトル | Lymphocytes influence Leishmania major pathogenesis in a strain-dependent manner | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Musa, Md. Abu
× Musa, Md. Abu× Nakamura, Risa× Hena, Asma× Varikuti, Sanjay× Nakhasi, Hira L.× Goto, Yasuyuki× Satoskar, Abhay R.× Hamano, Shinjiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis and is caused by several species of Leishmania parasite. Clinical presentation of CL varies from a self-healing infection to a chronic form of the disease determined by the virulence of infecting Leishmania species and host immune responses to the parasite. Mouse models of CL show contradictory roles of lymphocytes in pathogenesis, while acquired immune responses are responsible for host protection from diseases. To reconcile the inconclusive roles of acquired immune responses in pathogenesis, we infected mice from various genetic backgrounds with two pathogenic strains of Leishmania major, Friedlin or 5ASKH, and assessed the outcome of the infections. Our findings showed that the genetic backgrounds of L. major determine the impact of lymphocytes for pathogenesis. In the absence of lymphocytes, L. major Friedlin induced the lowest inflammatory reaction and pathology at the site of infection, while 5ASKH infection induced a strong inflammatory reaction and severe pathology. Lymphocytes ameliorated 5ASKH mediated pathology, while it exacerbated pathology during Friedlin infection. Excess inflammatory reactions, like the recruitment of macrophages, neutrophils, eosinophils and production of pro-inflammatory cytokines, together with uncontrolled parasite growth in the absence of lymphocytes during 5ASKH infection may induce severe pathology development. Taken together our study provides insight into the impact of differences in the genetic background of Leishmania on CL pathogenesis. |
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書誌情報 |
PLOS Neglected Tropical Diseases 巻 13, 号 11, p. e0007865, 発行日 2019-11-18 |
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出版者 | ||||||
出版者 | Public Library of Science | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19352727 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19352735 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1371/journal.pntd.0007865 | |||||
権利 | ||||||
権利情報 | This is an open access article, free of allcopyright, and may be freely reproduced,distributed, transmitted, modified, built upon, orotherwise used by anyone for any lawful purposeThe work is made available under the Creative Commons CC0 public domain dedication.. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PLoS neglected tropical diseases, 13(11), e0007865; 2019 |